• Il Yeong Park
  • Soo Jae Lee
Il Yeong Park

Education & Career:

  • 1977-1985 B.S. College of Pharmacy, Seoul National University
  • 1985-1987 M.S. Graduate School, Seoul National University
  • 1987-1992 Ph.D. Graduate School, Seoul National University
  • 1992-1994 Post-Doctor, Korea Research Institute of Chemical Technology
  • 1994-1995 Research Associate, Washington State University, USA
  • 1995-present (Assistant, Associate) Professor, College of Pharmacy, Chungbuk National University
  • 2002-2004 Visiting Scholar, Washington State University, USA
  • 2015-2017 Dean, College of Pharmacy, Chungbuk National University
  • 2017-2018 Director, Research Institute for Development of Pharmaceutical Resources, Chungbuk National University

Research Areas

  1. Structures of Bioactive Principles and their Activity Relationships

    The Redox Center of a Heat-stable Protein, Rubredoxin
  2. Understanding Cancer

    Role of RUNX3 for the ‘R-Point’ in the Cell Cycle


Selected Publications

  1. Yang Bae Kim, Chong-Kook Kim, Il Yeong Park; An Approach to Computer-Aided Drug Design, Pharmacon, 21(1), 20-29 (1991)
  2. X-Z Chi, J-W Lee, Y-S Lee, IY Park, Y Ito and S-C Bae; Runx3 plays a critical role in restriction-point and defense against cellular transformation Oncogene 36, 6884–6894 (2017)
  3. Ryuji Yamazawa, Chimari Jiko, Saehae Choi, Il Yeong Park, Atsushi Nakagawa, Eiki Yamashita, Soo Jae Lee; Structural Basis for Selective Binding of Export Cargoes by Exportin-5. Structure 26(10) 1393-1398 (2018)
  4. Jung-Won Lee, Da-Mi Kim, Ju-Won Jang, Tae-Geun Park, Soo-Hyun Song, You-Soub Lee, Xin-Zi Chi, Il Yeong Park, Jin-Won Hyun, Yoshiaki Ito and Suk-Chul Bae; RUNX3 regulates cell cycle-dependent chromatin dynamics by functioning as a pioneer factor of the restriction-point, Nature Communications 10:1897 (2019)
Soo Jae Lee

Education & Career

  • 2001 Osaka University PhD in Macromolecular Science
  • 1999 Osaka University MS in Macromolecular Science
  • 1989 Seoul National University BS in Pharmacy
  • 1989 – 1996 ChungWae Pharm. Co., Senior Scientist
  • 2002 - 2004 Osaka University, Post-doctoral fellow (Department of Medicine)
  • 2004 - 2006 MRC-LMB, Cambridge, UK, Post-doctoral fellow (Structural Studies)
  • 2006 - present Chungbuk National University, Professor (Department of Manufacturing Pharmacy)
  • 2007 - 2009 Chairman, Department of Manufacturing Pharmacy
  • 2017 - 2019 Deputy Dean, College of Pharmacy

Honor and Awards

  • 1996 - 2001 Japanese Government Scholorship(Monbusho Scholarship)
  • 2002 - 2004 JSPS Postdoctoral Fellowship for Foreign Researchers
  • 2004 - 2006 EMBO Fellowship

Research Areas

    Our group at Chungbuk National University has been focused on the elucidation of structure-function relationship of protein-protein or protein-RNA complexes, especially nuclear transport related protein complexes including importin- family. A eukaryotic cell is divided into two major compartments, nucleus and cytoplasm by nuclear envelope. Intracellular signals are transmitted via the continuous and bi-directional transport of proteins between the nucleus and the cytoplasm through nuclear pores. To elucidate the molecular basis for such intracellular communication in atomic level, we crystallize and solve the structure of nuclear-transport carrier proteins.

    Recently, we expanded our research interests with protein drugs including antibody. Collaboration with Osong KBIO for the X-ray structural analysis of virus antibody-antigen complex are in progress.


Selected Publications

  1. Yamazawa R., Jiko C., Choi S., Park I.Y., Nakagawa A., Yamashita E. a, Lee S.J. a, (2018) Structural Basis for Selective Binding of Export Cargoes by Exportin-5. Structure 2018 Oct 2;26(10):1393-1398 ( a corresponding author)
  2. Song J., Kose S. a, Watanabe A., Son S.Y., Choi S., Hong H., Yamashita E., Park IY., Imamoto N. a, Lee S.J. a (2015) Structural and functional analysis of Hikeshi, a new nuclear transport receptor of Hsp70s. Acta Crystallogr D Biol Crystallogr. 2015 Mar 1;71(Pt 3):473-83. ( a corresponding author)
  3. Choi S., Yamashita E., Yasuhara N., Song J., Son S.Y., Won Y.H., Hong H.R., Shin Y.S., Sekimoto T., Park I.Y., Yoneda Y. a, Lee S.J. a (2014) Structural basis for the selective nuclear import of the C2H2 zinc-finger protein Snail by importin β. Acta Crystallogr D Biol Crystallogr. 2014 Apr;70(Pt 4):1050-60. ( a corresponding author)
  4. Wyszynski FJ, Lee SS, Yabe T, Wang H, Gomez-Escribano JP, Bibb MJ, Lee SJ, Davies GJ, Davis BG.(2012) Biosynthesis of the tunicamycin antibiotics proceeds via unique exo-glycal intermediates. Nature Chemistry 4, 7, 539-546
  5. Lee S.J a, Jiko C, Yamashita E, Tsukihara T a.(2011) Selective nuclear export mechanism of small RNAs. Curr. Opi. Struct. Biol. 21, 1, 101-108 (a corresponding author)
  6. Okada C*., Yamashita E*., Lee S.J*,a., Shibata S., Katahira J., Nakagawa A., Yoneda Ya., Tsukihara Ta. A high-resolution structure of the pre-microRNA nuclear export machinery Science 27, 326, 1275-1279 ( * equally contributed author,  a corresponding author )
  7. Lee S.J., Ogasahara K., Ma J., Nishio K., Ishida M., Yamagata Y., Tsukihara T., Yutani K. (2005) Conformational Changes in the Tryptophan Synthase from a Hyperthermophile upon a2b2 Complex Formation : Crystal Structure of the Complex Biochemistry 44, 11417-11427
  8. Lee S.J., Matsuura Y., Liu S.M., Stewart M. (2005) Structural basis for nuclear import complex dissociation by RanGTP. Nature 435, 7042, 693-696.
  9. Tsunehiro M., Takeshi H., Yukiko Y., Lee S.J., Tomoki C., Kazuhiro I, Yoshiki Y., Koichi K., Tomitake T., Keiji T. (2004) Structural basis of sugar-recognizing ubiquitin ligase. Nat. Struc. Mol. Biol., 11, 365-370.
  10. Lee S.J., Sekimoto T., Yamashita E., Nagoshi E., Nakagawa A., Sakai H., Imamoto N., Tsukihara T., Yoneda Y. (2003) The structure of importin-beta bound to SREBP-2: nuclear import of a transcription factor. Science. 302, 1571-1575.