Education & Career

• 1988-1992: BS, College of Pharmacy, Chungbuk National University
• 1992-1994: MS, College of Pharmacy, Chungbuk National University
• 1994-1999: Ph.D., College of Pharmacy, Chungbuk National University
• 1999-2001: Post Doc, Korea Research Institute of Bioscience and Biotechnology (KRIBB)
• 2001-2003: Post Doc, College of Pharmacy, University of Illinois at Chicago, U.S.A.
• 2003-present: Professor, College of Pharmacy, Chungbuk National University
• 2009-2011: Vice Dean, College of Pharmacy, Chungbuk National University
• 2014-2015: Visiting Scholar, College of Pharmacy, University of Illinois at Chicago, U.S.A.

Research Areas

1. 천연물 유래 생리활성 물질 분리정제 및 구조규명
   

   

2. 식물유래 항염증 활성물질 분리정제
   

   

3. 천연물 대사체분석

   

Selected Publications

1. Lathyrane-Type Diterpenoids from the Seeds of Euphorbia lathyris L. with Inhibitory Effects on NO Production in RAW 264.7 Cells. Lee JW, Jin Q, Jang H, Kim JG, Lee D, Kim Y, Hong JT, Lee MK, Hwang BY. Chem Biodivers. 15(10): e1800144 (2018)
2. Dimeric- and trimeric sesquiterpenes from the flower of Inula japonica. Jin Q, Lee JW, Jang H, Lee HL, Kim JG, Wu W, Lee D, Kim EH, Kim Y, Hong JT, Lee MK, Hwang BY. Phytochemistry. 155: 107-113 (2018)
3. Nitric oxide inhibitory constituents from Siegesbeckia pubescens. Jang H, Lee JW, Kim JG, Hong HR, Le TPL, Hong JT, Kim Y, Lee MK, Hwang BY. Bioorg Chem. 80: 81-85 (2018)
4. Melanogenesis inhibitory pregnane glycosides from Cynanchum atratum. Jin Q, Han XH, Yun CY, Lee C, Lee JW, Lee D, Lee MK, Jung SH, Hong JT, Kim Y, Hwang BY. Bioorg Med Chem Lett. 28(7): 1252-1256 (2018)
5. Phenolic amides from Tribulus terrestris and their inhibitory effects on nitric oxide production in RAW 264.7 cells. Kim HS, Lee JW, Jang H, Le TPL, Kim JG, Lee MS, Hong JT, Lee MK, Hwang BY. Arch Pharm Res. 41(2): 192-195 (2018)
6. Chemical Constituents Isolated from Bletilla striata and Their Inhibitory Effects on Nitric Oxide Production in RAW 264.7 Cells. Bae JY, Lee JW, Jin Q, Jang H, Lee D, Kim Y, Hong JT, Lee MK, Lee MS, Hwang BY. Chem Biodivers. 14(2): e1600243 (2017)
7. Dimeric sesquiterpene and thiophenes from the roots of Echinops latifolius. Jin Q, Lee JW, Jang H, Choi JE, Kim HS, Lee D, Hong JT, Lee MK, Hwang BY. Bioorg Med Chem Lett. 26(24): 5995-5998 (2016)
8. Sesquiterpenes from Inula japonica with Inhibitory Effects on Nitric Oxide Production in Murine Macrophage RAW 264.7 Cells. Jin Q, Lee JW, Jang H, Choi JE, Lee D, Hong JT, Kim Y, Lee MK, Hwang BY. J Nat Prod. 79(6): 1548-1553 (2016)
9. Jatrophane and ingenane-type diterpenoids from Euphorbia kansui inhibit the LPS-induced NO production in RAW 264.7 cells. Lee JW, Jin Q, Jang H, Lee D, Han SB, Kim Y, Hong JT, Lee MK, Hwang BY. Bioorg Med Chem Lett. 26(14): 3351-3354 (2016)
10. Diterpenoids from the Roots of Euphorbia fischeriana with Inhibitory Effects on Nitric Oxide Production. Lee JW, Lee C, Jin Q, Jang H, Lee D, Lee HJ, Shin JW, Han SB, Hong JT, Kim Y, Lee MK, Hwang BY. J Nat Prod. 79(1): 126-131 (2016)
11. Sesquiterpenoids from Tussilago farfara inhibit LPS-induced nitric oxide production in macrophage RAW 264.7 cells. Jang H, Lee JW, Lee C, Jin Q, Choi JY, Lee D, Han SB, Kim Y, Hong JT, Lee MK, Hwang BY. Arch Pharm Res. 39(1): 127-132 (2016)
12. Biflavones and Furanone Glucosides from Zabelia tyaihyonii. Jang H, Lee JW, Jin Q, Kim SY, Lee D, Hong JT, Kim YS, Lee MK, Hwang BY. Hel Chim Acta. 98(10): 1419-1425 (2015)
13. neo-Clerodane Diterpenoids from Scutellaria barbata and Their Inhibitory Effects on LPS-Induced Nitric Oxide Production. Yeon ET, Lee JW, Lee C, Jin Q, Jang H, Lee D, Ahn JS, Hong JT, Kim Y, Lee MK, Hwang BY. J Nat Prod. 78(9): 2292-2296 (2015)
14. Geranylated flavanones from Paulownia coreana and their inhibitory effects on nitric oxide production. Jin Q, Lee C, Lee JW, Lee D, Kim Y, Hong JT, Kim JS, Kim JH, Lee MK, Hwang BY. Chem Pharm Bull. 63(5): 384-387 (2015)
15. Isolation and Characterization of Dammarane-Type Saponins from Gynostemma pentaphyllum and Their Inhibitory Effects on IL-6-Induced STAT3 Activation. Lee C, Lee JW, Jin Q, Jang H, Jang HJ, Rho MC, Lee MK, Lee CK, Lee MK, Hwang BY. J Nat Prod. 78(5): 971-976 (2015)
16. Two New Iridoids from the Stem of Catalpa ovata. Han XH, Lee C, Lee JW, Jin Q, Jang H, Lee HJ, Lee D, Lee SJ, Hong JT, Lee MK, Hwang BY. Hel Chim Acta. 98(3): 381-385 (2015)
17. Inhibitory constituents of Sophora tonkinensis on nitric oxide production in RAW 264.7 macrophages. Lee JW, Lee JH, Lee C, Jin Q, Lee D, Kim Y, Hong JT, Lee MK, Hwang BY. Bioorg Med Chem Lett. 25(4): 960-962 (2015)
18. Silvestrol and episilvestrol, potential anticancer rocaglate derivatives from Aglaia silvestris. Hwang BY, Su BN, Chai H, Mi Q, Kardono LB, Afriastini JJ, Riswan S, Santarsiero BD, Mesecar AD, Wild R, Fairchild CR, Vite GD, Rose WC, Farnsworth NR, Cordell GA, Pezzuto JM, Swanson SM, Kinghorn AD. J Org Chem. 69(10): 3350-3358 (2004)
19. Lignans from Saururus chinensis inhibiting the transcription factor NF-kappaB. Hwang BY, Lee JH, Nam JB, Hong YS, Lee JJ. Phytochemistry. 64(3): 765-771 (2003)
20. Antimicrobial constituents from goldenseal (the Rhizomes of Hydrastis canadensis) against selected oral pathogens. Hwang BY, Roberts SK, Chadwick LR, Wu CD, Kinghorn AD. Planta Med. 69(7): 623-627 (2003)

Education & Career

• 1988-1992: BS, College of Pharmacy, Seoul National University
• 1992-1994: MS, Synthetic Medicinal Chemistry, Seoul National University
• 1994-2000: Ph.D, Synthetic Medicinal Chemistry, Seoul National University
• 2000-2001: Post Doc. National Institute of Health, Korea
• 2001-2003: Post Doc. NIDDK, National Institute of Health, USA
• 2004-2005: Research associate, Research Institute of Pharmaceutical Science, Seoul National University
• 2006-2007: Director, Institute for Life Science, Elcom Science Co.Ltd.
• 2008-2008: Research Professor, Institute of Nano-Bio Technology, Ewha Womans University
• 2008-present: Assistant Professor, College of Pharmacy, Chungbuk National University

Research Areas

1. 천연물의 성분 연구
   

   

2. 천연물의 부위, 성숙단계 및 배양조건에 따른 성분 비교
   

   

Selected Publications

1. Kim SB, Liu Q, Ahn JH, Jo YH, Turk A, Hong IP, Han SM, Hwang BY, Lee MK (2018). Polyamine derivatives from the bee pollen of Quercus mongolia with tyrosinase inhibitory activity. Bioorganic Chemistry 81: 127-133
2. Ahn JH, Jo YH, Kim SB, Turk A, Oh KE, Hwang BY, Lee KY, Lee MK (2018). Identification of antioxidant constituents of the aerial part of Plantago asiatica using LC–MS/MS coupled DPPH assay. Phytochemistry Letters 26: 20-24
3. Jang JY, Shin H, Lim JW, Ahn JH, Jo YH, Lee KY, Hwang BY, Jung SJ, Kang SY, Lee MK (2018). Comparison of antibacterial activity and phenolic constituents of bark, lignum, leaves and fruit of Rhus verniciflua. PLoS One. 13(7):e0200257.
4. Song DH, Jo YH, Ahn JH, Kim SB, Yun CY, Kim Y, Hwang BY, Lee MK (2018). Sesquiterpenes from fruits of Torilis japonica with inhibitory activity on melanin synthesis in B16 cells. J Nat Med. 72, 155-160.
5. Yang HH, Oh KE, Jo YH, Ahn JH, Liu Q, Turk A, Jang JY, Hwang BY, Lee KY, Lee MK (2018). Characterization of tyrosinase inhibitory constituents from the aerial parts of Humulus japonicus using LC-MS/MS coupled online assay. Bioorg Med Chem.  15;26(2):509-515.
   
   
6. Ahn JH, Mo EJ, Jo YH, Kim SB, Hwang BY, Lee MK (2017). Variation of loganin content in Cornus officinalis fruits at different extraction conditions and maturation stages. Biosci Biotechnol Biochem. 81(10):1973-1977.
   
7. Mo EJ, Ahn JH, Jo YH, Kim SB, Hwang BY, Lee MK (2017). Inositol Derivatives and Phenolic Compounds from the Roots of Taraxacum coreanum. Molecules. 14;22(8). E1349.
   
8. Jo YH, Kim SB, Liu Q, Hwang BY, Lee MK (2017). Prenylated Xanthones from the Roots of Cudrania tricuspidata as Inhibitors of Lipopolysaccharide-Stimulated Nitric Oxide Production. Arch Pharm (Weinheim). 350, E1600263
   
9. Liu Q, Jo YH, Kim SB, Jin Q, Hwang BY, Lee MK (2016). Sesquiterpenes from the roots of Lindera strychnifolia with inhibitory effects on nitric oxide production in RAW 264.7 cells. Bioorg Med Chem Lett. 15;26(20):4950-4954
   
10. Lee JW, Mo EJ, Choi JE, Jo YH, Jang H, Jeong JY, Jin Q, Chung HN, Hwang BY, Lee MK (2016) Effect of extraction conditions of Red Ginseng on antioxidant activity, extraction yield and the contents of ginsenoside Rg1 and phenolics: Optimization using response surface methodology. J Ginseng Res 40: 229-236.