Education & Career

• 1992-1999: B.S. in Food Science & Nutrition, Soonchunhyang University
• 1999-2001: M.S. in Food Science & Nutrition, Soonchunhyang University
• 2001-2004: Ph.D. in Molecular Nutrition, Soonchunhyang University
• 2004-2007: Research Professor/Postdoctoral Fellow, College of Pharmacy and School of Veterinary Medicine, Chungbuk National University
• 2007-2008: Postdoctoral Fellow, Department of Pathology, College of Medicine, University of Iowa, Iowa City, USA
• 2008-2013: Instructor/Postdoctoral Fellow, Department of Biomedical Engineering and Division of Cardiology, School of Medicine, Emory University and Georgia Institute of Technology, Atlanta, Georgia, USA
• 2014-2015: Research Professor, Department of Applied Bioscience, College of Agriculture and Life Science, Kyungpook Nationation University
• 2015-2017: Research Professor, MRC, College of Pharmacy, Chungbuk National University
• 2017-2019: Chief Technology Officer, Life Science R&D Center, NovaKmed Co. Ltd.
• 2019-present: Assistant Professor, College of Pharmacy, Chungbuk National University

Research Areas

1. Exploring the role of blood flow shear stress in endothelial cell physiology and vascular diseases
   
   
   
2. Development of novel animal model for endothelial dysfunction and vascular diseases
   
   
   
3. Identification of flow-mechanosensitive genes and physiological validation
   
   
   

Selected Publications

1. FlexPro MD®, a Combination of Krill Oil, Astaxanthin and Hyaluronic Acid, Reduces Pain Behavior and Inhibits Inflammatory Response in Monosodium Iodoacetate-Induced Osteoarthritis in Rats. Park MH, Jung JC, Hill S, Cartwright E, Dohnalek MH, Yu M, Jun HJ, Han SB, Hong JT, Son DJ. Nutrients. 2020 Mar 30;12(4). pii: E956.
2. Anxiolytic-like effects of the ethanol extract of Magnolia obovata leaves through its effects on GABA-benzodiazepine receptor and neuroinflammation. Ham HJ, Lee YS, Yun J, Han SB, Son DJ, Hong JT. Behav Brain Res. 2020 Apr 6;383:112518.
3. Wheat Extract Oil (WEO) Attenuates UVB-Induced Photoaging via Collagen Synthesis in Human Keratinocytes and Hairless Mice. Son DJ, Jung JC, Choi YM, Ryu HY, Lee S, Davis BA. Nutrients. 2020 Jan 22;12(2). pii: E300.
4. Fermented Korean Red Ginseng Extract Enriched in Rd and Rg3 Protects against Non-Alcoholic Fatty Liver Disease through Regulation of mTORC1. Choi SY, Park JS, Shon CH, Lee CY, Ryu JM, Son DJ, Hwang BY, Yoo HS, Cho YC, Lee J, Kim JW, Roh YS. Nutrients. 2019 Dec 4;11(12). pii: E2963.
5. Suppression of metastasis through inhibition of chitinase 3-like 1 expression by miR-125a-3p-mediated up-regulation of USF1. Kim KC, Yun J, Son DJ, Kim JY, Jung JK, Choi JS, Kim YR, Song JK, Kim SY, Kang SK, Shin DH, Roh YS, Han SB, Hong JT. Theranostics. 2018 Aug 7;8(16):4409-4428
6. PRDX6 Inhibits Neurogenesis through Downregulation of WDFY1-Mediated TLR4 Signal. Yeo IJ, Park MH, Son DJ, Kim JY, Nam KT, Hyun BK, Kim SY, Jung MH, Song MJ, Chun HO, Lee TH, Han SB, Hong JT. Mol Neurobiol. 2019 May;56(5):3132-3144.
7. Piperlongumine Improves Lipopolysaccharide-Induced Amyloidogenesis by Suppressing NF-KappaB Pathway. Gu SM, Lee HP, Ham YW, Son DJ, Kim HY, Oh KW, Han SB, Yun J, Hong JT. Neuromolecular Med. 2018 Sep;20(3):312-327.
8. IL-32 gamma reduces lung tumor development through upregulation of TIMP-3 overexpression and hypomethylation. Yun J, Park MH, Son DJ, Nam KT, Moon DB, Ju JH, Hwang OK, Choi JS, Kim TH, Jung YS, Hwang DY, Han SB, Yoon DY, Hong JT. Cell Death Dis. 2018 Feb 21;9(3):306.
9. Atherosclerosis is exacerbated by chitinase-3-like-1 in amyloid precursor protein transgenic mice. Jung YY, Kim KC, Park MH, Seo Y, Park H, Park MH, Chang J, Hwang DY, Han SB, Kim S, Son DJ, Hong JT. Theranostics. 2018 Jan 1;8(3):749-766.
10. Antarctic Krill Oil Diet Protects against Lipopolysaccharide-Induced Oxidative Stress, Neuroinflammation and Cognitive Impairment. Choi JY, Jang JS, Son DJ, Im HS, Kim JY, Park JE, Choi WR, Han SB, Hong JT. Int J Mol Sci. 2017 Nov 28;18(12). pii: E2554.
11. MMPP Attenuates Non-Small Cell Lung Cancer Growth by Inhibiting the STAT3 DNA-Binding Activity via Direct Binding to the STAT3 DNA-Binding Domain. Son DJ, Zheng J, Jung YY, Hwang CJ, Lee HP, Woo JR, Baek SY, Ham YW, Kang MW, Shong M, Kweon GR, Song MJ, Jung JK, Han SB, Kim BY, Yoon DY, Choi BY, Hong JT. Theranostics. 2017 Oct 16;7(18):4632-4642.
12. Interleukin-32α Inhibits Endothelial Inflammation, Vascular Smooth Muscle Cell Activation, and Atherosclerosis by Upregulating Timp3 and Reck through suppressing microRNA-205 Biogenesis. Son DJ, Jung YY, Seo YS, Park H, Lee DH, Kim S, Roh YS, Han SB, Yoon DY, Hong JT. Theranostics. 2017 Jun 1;7(8):2186-2203.
13. Parkin Knockout Inhibits Neuronal Development via Regulation of Proteasomal Degradation of p21. Park MH, Lee HJ, Lee HL, Son DJ, Ju JH, Hyun BK, Jung SH, Song JK, Lee DH, Hwang CJ, Han SB, Kim S, Hong JT. Theranostics. 2017 May 12;7(7):2033-2045.
14. Activated Natural Killer Cells Mediate the Suppressive Effect of Interleukin-4 on Tumor Development via STAT6 Activation in an Atopic Condition Melanoma Model. Son DJ, Jung YY, Park MH, Lee HL, Song MJ, Yoo HS, Hwang DY, Han SB, Hong JT. Neoplasia. 2017 Jul;19(7):537-548.
15. Loss of Parkin reduces inflammatory arthritis by inhibiting p53 degradation. Jung YY, Son DJ, Lee HL, Kim DH, Song MJ, Ham YW, Kim Y, Han SB, Park MH, Hong JT. Redox Biol. 2017 Aug;12:666-673.
16. (E)-2-methoxy-4-(3-(4-methoxyphenyl)prop-1-en-1-yl)phenol suppresses ovarian cancer cell growth via inhibition of ERK and STAT3. Zheng J, Son DJ, Lee HL, Lee HP, Kim TH, Joo JH, Ham YW, Kim WJ, Jung JK, Han SB, Hong JT. Mol Carcinog. 2017 Sep;56(9):2003-2013.
17. Interleukin 32, inflammation and cancer. Hong JT, Son DJ, Lee CK, Yoon DY, Lee DH, Park MH. Pharmacol Ther. 2017 Jun;174:127-137.
18. Inhibitory effect of punicalagin on lipopolysaccharide-induced neuroinflammation, oxidative stress and memory impairment via inhibition of nuclear factor-kappaB. Kim YE, Hwang CJ, Lee HP, Kim CS, Son DJ, Ham YW, Hellström M, Han SB, Kim HS, Park EK, Hong JT. Neuropharmacology. 2017 May 1;117:21-32.
19. Parkin deficiency exacerbate ethanol-induced dopaminergic neurodegeneration by P38 pathway dependent inhibition of autophagy and mitochondrial function. Hwang CJ, Kim YE, Son DJ, Park MH, Choi DY, Park PH, Hellström M, Han SB, Oh KW, Park EK, Hong JT. Redox Biol. 2017 Apr;11:456-468.
20. Piperlongumine attenuates experimental autoimmune encephalomyelitis through inhibition of NF-kappaB activity. Gu SM, Yun J, Son DJ, Kim HY, Nam KT, Kim HD, Choi MG, Choi JS, Kim YM, Han SB, Hong JT. Free Radic Biol Med. 2017 Feb;103:133-145.
21. Enhanced dopaminergic neurotoxicity mediated by MPTP in IL-32β transgenic mice. Jung YY, Katila N, Neupane S, Shadfar S, Ojha U, Bhurtel S, Srivastav S, Son DJ, Park PH, Yoon DY, Hong JT, Choi DY. Neurochem Int. 2017 Jan;102:79-88.
22. Novel synthetic (E)-2-methoxy-4-(3-(4-methoxyphenyl) prop-1-en-1-yl) phenol inhibits arthritis by targeting signal transducer and activator of transcription 3. Son DJ, Kim DH, Nah SS, Park MH, Lee HP, Han SB, Venkatareddy U, Gann B, Rodriguez K, Burt SR, Ham YW, Jung YY, Hong JT. Sci Rep. 2016 Nov 15;6:36852.
23. Epothilones Suppress Neointimal Thickening in the Rat Carotid Balloon-Injury Model by Inducing Vascular Smooth Muscle Cell Apoptosis through p53-Dependent Signaling Pathway. Son DJ, Jung JC, Hong JT. PLoS One. 2016 May 24;11(5):e0155859.
24. Piperlongumine inhibits lung tumor growth via inhibition of nuclear factor kappa B signaling pathway. Zheng J, Son DJ, Gu SM, Woo JR, Ham YW, Lee HP, Kim WJ, Jung JK, Hong JT. Sci Rep. 2016 May 20;6:26357.
25. Glutathione peroxidase 1 deficiency attenuates concanavalin A-induced hepatic injury by modulation of T-cell activation. Lee DH, Son DJ, Park MH, Yoon DY, Han SB, Hong JT. Cell Death Dis. 2016 Apr 28;7:e2208.
26. Synergistic inhibitory effect of cetuximab and tectochrysin on human colon cancer cell growth via inhibition of EGFR signal. Park MH, Hong JE, Hwang CJ, Choi M, Choi JS, An YJ, Son DJ, Hong JT. Arch Pharm Res. 2016 May;39(5):721-9.
27. Effect of Ixeris dentata Nakai Extract on Nitric Oxide Production and Prostaglandin E2 Generation in LPS-stimulated RAW264.7 Cells. Jung YY, Hong JT, Han SB, Park YH, Son DJ. Immune Netw. 2015 Dec;15(6):325-30.
28. Synergistic Inhibitory Effects of Cetuximab and Cisplatin on Human Colon Cancer Cell Growth via Inhibition of the ERK-Dependent EGF Receptor Signaling Pathway. Son DJ, Hong JE, Ban JO, Park JH, Lee HL, Gu SM, Hwang JY, Jung MH, Lee DW, Han SB, Hong JT. Biomed Res Int. 2015;2015:397563.
29. Multifunctional Nanoparticles Facilitate Molecular Targeting and miRNA Delivery to Inhibit Atherosclerosis in ApoE(-/-) Mice. Kheirolomoom A, Kim CW, Seo JW, Kumar S, Son DJ, Gagnon MK, Ingham ES, Ferrara KW, Jo H. ACS Nano. 2015 Sep 22;9(9):8885-97.
30. Anti-Diabetic and Hepato-Renal Protective Effects of Ziyuglycoside II Methyl Ester in Type 2 Diabetic Mice. Son DJ, Hwang SY, Kim MH, Park UK, Kim BS. Nutrients. 2015 Jul 7;7(7):5469-83.
31. Bee venom ameliorates lipopolysaccharide-induced memory loss by preventing NF-kappaB pathway. Gu SM, Park MH, Hwang CJ, Song HS, Lee US, Han SB, Oh KW, Ham YW, Song MJ, Son DJ, Hong JT. J Neuroinflammation. 2015 Jun 26;12:124.
32. Disturbed flow enhances inflammatory signaling and atherogenesis by increasing thioredoxin-1 level in endothelial cell nuclei. Go YM, Son DJ, Park H, Orr M, Hao L, Takabe W, Kumar S, Kang DW, Kim CW, Jo H, Jones DP. PLoS One. 2014 Sep 29;9(9):e108346.
33. Piperine inhibits the activities of platelet cytosolic phospholipase A2 and thromboxane A2 synthase without affecting cyclooxygenase-1 activity: different mechanisms of action are involved in the inhibition of platelet aggregation and macrophage inflammatory response. Son DJ, Akiba S, Hong JT, Yun YP, Hwang SY, Park YH, Lee SE. Nutrients. 2014 Aug 22;6(8):3336-52.
34. Bioassay-guided isolation and identification of anti-platelet-active compounds from the root of Ashitaba (Angelica keiskei Koidz.). Son DJ, Park YO, Yu C, Lee SE, Park YH. Nat Prod Res. 2014;28(24):2312-6.
35. Flow-dependent epigenetic DNA methylation regulates endothelial gene expression and atherosclerosis. Dunn J, Qiu H, Kim S, Jjingo D, Hoffman R, Kim CW, Jang I, Son DJ, Kim D, Pan C, Fan Y, Jordan IK, Jo H. J Clin Invest. 2014 Jul;124(7):3187-99.
36. Prevention of abdominal aortic aneurysm by anti-microRNA-712 or anti-microRNA-205 in angiotensin II-infused mice. Kim CW, Kumar S, Son DJ, Jang IH, Griendling KK, Jo H. Arterioscler Thromb Vasc Biol. 2014 Jul;34(7):1412-21.
37. Flow-dependent regulation of genome-wide mRNA and microRNA expression in endothelial cells in vivo. Kumar S, Kim CW, Son DJ, Ni CW, Jo H. Sci Data. 2014 Oct 28;1:140039.
38. The atypical mechanosensitive microRNA-712 derived from pre-ribosomal RNA induces endothelial inflammation and atherosclerosis. Son DJ, Kumar S, Takabe W, Kim CW, Ni CW, Alberts-Grill N, Jang IH, Kim S, Kim W, Won Kang S, Baker AH, Woong Seo J, Ferrara KW, Jo H. Nat Commun. 2013;4:3000.
39. Piperlongumine inhibits LMP1/MYC-dependent mouse B-lymphoma cells. Han SS, Tompkins VS, Son DJ, Kamberos NL, Stunz LL, Halwani A, Bishop GA, Janz S. Biochem Biophys Res Commun. 2013 Jul 12;436(4):660-5.
40. Anti-inflammatory and antiatherogenic role of BMP receptor II in endothelial cells. Kim CW, Song H, Kumar S, Nam D, Kwon HS, Chang KH, Son DJ, Kang DW, Brodie SA, Weiss D, Vega JD, Alberts-Grill N, Griendling K, Taylor WR, Jo H. Arterioscler Thromb Vasc Biol. 2013 Jun;33(6):1350-9.
41. Piperlongumine inhibits atherosclerotic plaque formation and vascular smooth muscle cell proliferation by suppressing PDGF receptor signaling. Son DJ, Kim SY, Han SS, Kim CW, Kumar S, Park BS, Lee SE, Yun YP, Jo H, Park YH. Biochem Biophys Res Commun. 2012 Oct 19;427(2):349-54.
42. 8-Hydroxy-2-deoxyguanosine prevents plaque formation and inhibits vascular smooth muscle cell activation through Rac1 inactivation. Huh JY, Son DJ, Lee Y, Lee J, Kim B, Lee HM, Jo H, Choi S, Ha H, Chung MH. Free Radic Biol Med. 2012 Jul 1;53(1):109-21.
43. Dynamic immune cell accumulation during flow-induced atherogenesis in mouse carotid artery: an expanded flow cytometry method. Alberts-Grill N, Rezvan A, Son DJ, Qiu H, Kim CW, Kemp ML, Weyand CM, Jo H. Arterioscler Thromb Vasc Biol. 2012 Mar;32(3):623-32.
44. Discovery of novel mechanosensitive genes in vivo using mouse carotid artery endothelium exposed to disturbed flow. Ni CW, Qiu H, Rezvan A, Kwon K, Nam D, Son DJ, Visvader JE, Jo H. Blood. 2010 Oct 14;116(15):e66-73.

Patents

1. Methods and compositions for managing vascular conditions, Application No. 61/916,449(US)
2. Use of inhibitors of microRNA-miR-712/miR-205 to treat cardiovascular diseases and cancer, Application No. 61/904,026(US)
3. Use of inhibitors of microRNA-712 to treat atherosclerosis, Application No. 61/552,205 (US)
4. Composition for preventing or treating fatty liver disease comprising solid phase fermented red ginseng extract by cordyceps, Application No. 10-2019-0020474 (KR)
5. Pharmaceutical composition comprising epothilone B for the treating and preventing vascular restenosis, Registration No. 10-0860326 (KR)
6. Pharmaceutical composition comprising cinnamaldehyde derivatives for the treating and preventing inflammatory disease, Registration No. 10-0676761 (KR)
7. Inhibitor of nuclear factor-kappa B, Registration No. 10-0668229 (KR)