Education & Career

• 2001-2005 B.S. College of Pharmacy, Chungbuk National University, Republic of Korea.
  
• 2005-2007 M.S. Department of Pharmaceutics, College of Pharmacy, Chungbuk National University, Republic of Korea.
  
• 2007-2012 Ph.D. Department of Pharmaceutics, College of Pharmacy, Chungbuk National University, Republic of Korea.
  
• 2012~2015 Research Fellow, Research Center for Cell Fate Control (RCCFC) & College of Pharmacy, Sookmyung Women’s University, Seoul 04310, Republic of Korea.
  
• 2015~2017 Research Associate, Pharmaceutical Science Division, School of Pharmacy, University of Wisconsin-Madison, WI 53705-2222 USA.
  
• 2017~2018 Assistant Professor, College of Pharmacy and Natural Medicine Research Institute, Mokpo National University, Jeonnam 58554, Republic of Korea.
  
• 2018~present Assistant Professor, College of Pharmacy, Chungbuk National University, Cheongju 28160, Republic of Korea.

Research Areas

1. Systemic drug delivery system (micelle, liposome)






2. Local drug delivery system (thermosensitive gel: thermogel)



3. Targeting cancer stem cells



4. Pharmacokinetics and pharmacodynamics (PK/PD)



5. Interspecies scaling analysis



6. Angiogenesis

Selected Publications

1. Yu Tong Tam, Dae Hwan Shin, Karen E. Chen, Glen S. Kwon, Poly(ethylene glycol)-block-poly(D,L-lactic acid) micelles containing oligo (lactic acid)8-paclitaxel prodrug: In Vivo conversion and antitumor efficacy, J. Control. Release., 298, 186-193 (2019)
2. Jung Seok Kim, Dae Hwan Shin, and Jin-Seok Kim, Dual-targeting immunoliposomes using angiopep-2 and CD133 antibody for glioblastoma stem cells. J. Control. Release, 269, 245-257 (2018).
3. Dae Hwan Shin and Glen S. Kwon, Pre-clinical evaluation of a themosensitive gel containing epothilone B and mTOR/Hsp90 targeted agents in an ovarian tumor model. J. Control. Release, 268, 176-183 (2017).
4. Dae Hwan Shin and Glen S. Kwon, Epothilone B-based 3-in-1 polymeric micelle for anticancer drug therapy. Int. J. Pharm., 518, 307-311 (2017).
5. Celeste Alvarez, Dae Hwan Shin, and Glen S. Kwon, Reformulation of Fungizone by PEG-DSPE Micelles: Deaggregation and Detoxification of Amphotericin B. Pharm. Res., 33, 2098-2106 (2016).
6. Dae Hwan Shin, Yu Tong Tam, and Glen S. Kwon, Polymeric micelle nanocarriers in cancer research. Front. Chem. Sci. Eng., 10(3), 348-359 (2016).
7. Jeong Yeon Kang, Jieming Gao, Dae Hwan Shin, Celeste Alvarez, Weixiong Zhong, and Glen S. Kwon, Pharmacokinetics and Renal Toxicity of Monomeric Amphotericin B in Rats after a Multiple Dose Regimen. Pharm. Nanotechnol., 4, 16-23 (2016).
8. Na-Kyung Han, Dae Hwan Shin, Jung Seok Kim, Kwon Yeon Weon, Chang-Young Jang, and Jin-Seok Kim, Hyaluronan-conjugated Liposomes Encapsulating Gemcitabine for Targeting Breast Cancer Stem Cell. Int. J. Nanomed., 11, 1413-1425 (2016).
9. Dae Hwan Shin, Min-Ji Koo, Jung Seok Kim, and Jin-Seok Kim, Herceptin-conjugated Temperature-Sensitive Immunoliposomes Encapsulating Gemcitabine for Breast Cancer. Arch. Pharm. Res., 39(3) 350-358 (2016).
10. Dae Hwan Shin, Sang-Jin Lee, Jung Seok Kim, Jae-Ha Ryu, and Jin-Seok Kim, Synergistic effect of immunoliposomal gemcitabine and bevacizumab in glioblastoma stem cell-targeted therapy in vivo. J. Biomed. Nanotechnol. 11(11), 1989-2002 (2015).
11. Dae Hwan Shin, Seung Hyeok Park, Sung Woo Jeong, Oh-Seung Kwon, Chun-Woong Park, Kun Han, and Youn Bok Chung, Pharmacokinetic scaling of epirubicin using allometric and species-invariant time methods, J. Pharm. Investig., 45, 441-448 (2015).
12. Hye Jin Kim, Dae Hwan Shin, Eun Ah Lim, Jin-Seok Kim, Sustained-release formulation of sarpogrelate hydrochloride. Arch. Pharm. Res. 38(1), 35-41 (2015).
13. Dae Hwan Shin, Seong Hyeok Park, Sung Woo Jeong, Chun-Woong Park, Kun Han, Youn Bok Chung, Hepatic uptake of epirubicin by isolated rat hepatocytes and its biliary excretion after intravenous infusion in rats. Arch. Pharm. Res., 37(12) 1599-1606 (2014).
14. Shuhua Xuan, Dae Hwan Shin, Jin-Seok Kim, Angiopep-2-conjugated liposomes encapsulating γ-secretase inhibitor for targeting glioblastoma stem cells. J. Pharm. Investig., 44(7), 473-483 (2014).
15. Dae Hwan Shin, Shuhua Xuan, Woo-Young Kim, Gyu-Un Bae and Jin-Seok Kim. CD133 antibody-conjugated immunoliposomes encapsulating gemcitabine for targeting glioblastoma stem cells. J. Mater. Chem. B, 2, 3771-3781 (2014).
16. Sun-Kyung Lim, Dae Hwan Shin, Mi-Hee Choi and Jin-Seok Kim. Enhanced antitumor efficacy of gemcitabine-loaded temperature-sensitive liposome by hyperthermia in tumor-bearing mice. Drug Dev. Ind. Pharm., 40(4), 470-476 (2014).
17. Hyung-Mun Yun, Kyung-Ran Park, Hee Peum Lee, Dong Hun Lee, Miran Jo, Dea Hwan Shin, Do-Young Yoon, Sang Bae Han and Jin Tae Hong. PRDX6 promotes lung tumor progression via its GPx and iPLA2 activities. Free Radic. Biol. Med., 69, 367-376 (2014).
18. Dae Hwan Shin, Jae-Yeon Shim, Jung Hyun Kim, Seung Youn Lee, Shuhua Xuan, Woo-Young Kim, Kwon Yeon Weon and Jin-Seok Kim. Enhanced Anticancer Effect of Liposome Encapsulated Choline Kinase-siRNA in Mice. Macromol. Res., 22(3), 344-355 (2014).
19. Mihee Choi, Dae Hwan Shin, Jin-Seok Kim. Repositioning of zoledronic acid for breast cancer using transferrin-conjugated liposome. J. Pharm. Investig., 43, 461-469 (2013).
20. Dae Hwan Shin, Seong Hyeok Park, Oh-Seung Kwon, Chun-Woong Park, Kun Han, Youn Bok Chung. Validation of high-performance liquid chromatography method to determine epirubicin and its pharmacokinetics after intravenous bolus administration in rats. J. Pharm. Investig., 43, 243-249 (2013).
21. Bee Kim, Dae Hwan Shin, Hee Doo Kim, Jin-Seok Kim, Antitumor effect of a newly synthesized celecoxib derivative encapsulated in liposome. J. Pharm. Investig., 43, 101-106 (2013).
22. Seung Hyeok Park, Dae Hwan Shin, Han Jun Cho, Ju Bin Yim, Sung Cil Lim, Kun Han and Youn Bok Chung. Pharmacokinetics and Excretion into Expired Air of Urea, a Potential Diagnosis Reagent of Helicobacter pylori Infection. Kor. J. Clin. Pharm., 22(2) 160-166 (2012).
23. Jingshu Piao, Ji-Eun Lee, Dae Hwan Shin, Jin-Seok Kim. Pharmacokinetic study of mucoadhesive metformin pellets in rats. J. Pharm. Investig., 42, 133-137 (2012).
24. Dae Hwan Shin, Tai Sung Kim, Seong Hyeok Park, Si Hyun Kim, Han Jun Jo, Kun Han and Youn Bok Chung. Physicochemical Characteristics and Pharmacokintics of Ibuprofen Lysine Salts. Yakhak Hoeji, 55(3), 260-266 (2011).
25. Dae Hwan Shin, Jung Yeol Lee, Seong Hyeok Park, Gyeongbok Lee, Kun Han and Youn Bok Chung. HPLC Analysis and Pharmacokinetics of KAL-1120, a Novel Anti-inflammation Agent, in Rats. J. Kor. Pharm. Sci., 40(2), 101-107 (2010).
26. Dae Hwan Shin, Seong Hyeok Park and Youn Bok Chung. HPLC analysis of piroxicam in the rabbit plasma and its bioavailability after the transdermal administration of patches. J. Kor. Pharm. Sci., 39(3), 177-183 (2009).
27. Dae Hwan Shin, Kyu Seok Choi and Youn Bok Chung. Extensive intracellular accumulation of ID-6105, a novel anthracycline, in SK-OV-3 ovarian cancer cells. Arch. Pharm. Res., 31(10), 1355-1361 (2008).
28. Dae Hwan Shin, Kyu Seok Choi, Sang-Ae Park, Byung Suk Cho, Hong-Sub Lee, Jung-Su Ryu, Tae-Yong Kim, Chong-Kil Lee, Sukgil Song and Youn Bok Chung. Pharmacokinetics of guanosine in rats following intravenous or intramuscular administration of a 1:1 mixture of guanosine and acriflavine, a potential antitumor agent. Arch. Pharm. Res., 31(10), 1347-1353 (2008).
29. Dae Hwan Shin, Byung Suk Cho and Youn Bok Chung. Pharmacokinetics and Lymphatic Delivery of Oligopeptide after Intramuscular Injection of Oligopeptide-bearing Liposomes to Rats. J. Kor. Pharm. Sci., 38(3), 191-197 (2008).
30. Pung Sok Lee, Dae Hwan Shin and Youn Bok Chung. Effects of guanosine on the pharmacokinetics of acriflavine in rats following the administration of a 1:1 mixture of acriflavine and guanosine, a potential antitumor agent. Arch. Pharm. Res., 30(3), 372-380 (2007).
31. Pung Sok Lee, Dae Hwan Shin and Youn Bok Chung. Pharmacokinetics of arsenic hexaoxide, an anticancer compound, in rats. J. Kor. Pharm. Sci., 36(6), 377-383 (2006).

Patents

1. 젬시타빈이 포집된 면역 리포좀 및 베바시주맙을 유효성분으로 포함하는 교모세포종 예방 및 치료용 약학적 조성물 (특허번호 제 10-1735284 호, 등록일: 2017년 5월 8일)