Education & Career:

• 2000-2004: BS in Pharmacy, College of Pharmacy, Chungbuk National University
• 2004-2006: MS in Pharmacy, College of Pharmacy, Chungbuk National University
• 2006-2011: PhD in Pharmacy, College of Pharmacy, Chungbuk National University
• 2011-2012: Post Doc. College of Pharmacy, Chungbuk National University
• 2013-2013: Post Doc. Dept. of Chemistry, Duke University
• 2013-2019: Assistant Professor, College of Pharmacy, Kyungsung University
• 2019-2022: Associate Professor, College of Pharmacy, Kyungsung University
• 2022-present: Associate Professor, College of Pharmacy, Chungbuk National University

Research Areas

1. Medicinal Chemistry based on rational molecular modeling
2. Total synthesis of biologically active natural products
3. Development of new synthetic methodology
4. in silico docking study and machine learning in drug discovery

 

Selected Publications

1. Jo, A. #; Kwak, J.H. #;  Woo, S.-Y. #;  Kim, B.-Y.;  Son, Y.;  Choi, H.-S.;  Kim, J.;  Kwon, M.;  Cho, H.-R.;  Eo, S.-K.;  Nam, J. H.;  Kim, H.-S.;  Baryawno, N.;  Lee, D.; Kim, K., Oxime derivative TFOBO promotes cell death by modulating reactive oxygen species and regulating NADPH oxidase activity in myeloid leukemia. Sci Rep 2022, 12 (1), 7519.
2. Kwon, Y. M.;  Kim, S. H.;  Jung, Y. S.*; Kwak, J. H.*, Synthesis and Biological Evaluation of (S)-2-(Substituted arylmethyl)-1-oxo-1,2,3,4-tetrahydropyrazino[1,2-a]indole-3-carboxamide Analogs and Their Synergistic Effect against PTEN-Deficient MDA-MB-468 Cells. Pharmaceuticals (basel) 2021, 14 (10), 974.
3. Kwak, J. H. #;  Kim, Y. #;  Staatz, C. E.; Baek, I. H., Oral bioavailability and pharmacokinetics of esculetin following intravenous and oral administration in rats. Xenobiotica 2021, 51 (7), 811-817.
4. Kim, S. H.;  Kim, M.;  Kwon, D.;  Pyo, J. S.;  Kim, J. H.; Kwak, J. H.*; Jung, Y. S.*, N-Phenyl Cinnamamide Derivatives Protect Hepatocytes against Oxidative Stress by Inducing Cellular Glutathione Synthesis via Nuclear Factor (Erythroid-Derived 2)-Like 2 Activation. Molecules 2021, 26 (4), 1027.
5. Kim, D. K.;  Chung, S. Y.; Kwak, J. H.;  Kim, M. S.;  Staatz, C. E.;  Lee, H. S.; Baek, I. H., Pharmacokinetic interaction between dronedarone and ticagrelor following oral administration in rats. Xenobiotica 2021, 51 (2), 194-201.
6. Jung, Y.;  Hong, J. E.; Kwak, J. H.; Park, Y., Single-Step Approach toward Nitrones via Pyridinium Ylides: The DMAP-Catalyzed Reaction of Benzyl Halides with Nitrosoarenes. J Org Chem 2021, 86 (9), 6343-6350.
7. Ha, D. K.;  Kim, M. J.;  Han, N.; Kwak, J. H.*; Baek, I. H.*, Comparative Efficacy of Oral Calcitonin-Gene-Related Peptide Antagonists for the Treatment of Acute Migraine: Updated meta-analysis. Clin Drug Investig 2021, 41 (2), 119-132.
8. Jung, Y.;  Hong, J. E.;  Baek, S. T.;  Hong, S.; Kwak, J. H.; Park, Y., 4-Dimethylaminopyridine-Catalyzed metal-Free Aerobic Oxidation of Aryl alpha-Halo Esters to Aryl alpha-Keto Esters. ACS Omega 2020, 5 (36), 22951-22957.
9. Jo, J.;  Kim, S. H.;  Kim, H.;  Jeong, M.; Kwak, J. H.;  Han, Y. T.;  Jeong, J. Y.;  Jung, Y. S.; Yun, H., Discovery and SAR studies of novel 2-anilinopyrimidine-based selective inhibitors against triple-negative breast cancer cell line MDA-MB-468. Bioorg Med Chem Lett 2019, 29 (1), 62-65.
10. Kim, S. H. #;  Kwon, D. Y. #; Kwak, J. H. #;  Lee, S.;  Lee, Y. H.;  Yun, J.;  Son, T. G.; Jung, Y. S., Tunicamycin-Induced ER Stress is Accompanied with Oxidative Stress via Abrogation of Sulfur Amino Acids metabolism in the Liver. Int J Mol Sci2018, 19 (12).
11. Lee, Y. H.;  Kim, S. H.;  Lee, S.;  Kim, K. M.;  Jung, J. C.;  Son, T. G.;  Ki, S. H.;  Seo, W. D.; Kwak, J. H.;  Hong, J. T.; Jung, Y. S., Antioxidant Effect of Barley Sprout Extract via Enhancement of Nuclear Factor-Erythroid 2 Related Factor 2 Activity and Glutathione Synthesis. Nutrients 2017, 9 (11).
12. Kim, Y. J.;  Pyo, J. S.;  Jung, Y. S.*; Kwak, J. H.*, Design, synthesis, and biological evaluation of novel 1-oxo-1,2,3,4-tetrahydropyrazino[1,2-a]indole-3-carboxamide analogs in MCF-7 and MDA-MB-468 breast cancer cell lines. Bioorg Med Chem Lett 2017, 27 (3), 607-611.
13. Jo, J.;  Kim, S. H.;  Han, Y. T.; Kwak, J. H.; Yun, H., Recent Advances in Substrate-Controlled Asymmetric Cyclization for Natural Product Synthesis. Molecules 2017, 22 (7).
14. Lee, K.;  Lanier, M. L.; Kwak, J. H.*;  Kim, H.*; Hong, J.*, Advances in the synthesis of glycosidic macrolides: clavosolides A-D and cyanolide A. Nat Prod Rep 2016, 33 (12), 1393-1424. (*co-Corresponding; IF: 13.423; 0.81% in Chemistry, Medicinal)
15. Kim, B. W.;  More, S. V.;  Yun, Y. S.;  Ko, H. M.; Kwak, J. H.;  Lee, H.;  Suk, K.;  Kim, I. S.; Choi, D. K., A novel synthetic compound MCAP suppresses LPS-induced murine microglial activation in vitro via inhibiting NF-kB and p38 MAPK pathways. Acta Pharmacol Sin 2016, 37 (3), 334-43.

 

Patents

1. Prazinoindolone derivatives for treatment of breast cancer and process of preparation thereof (KR 10-1891657-0000)

Education & Career

• 2003 – 2009 : Ph.D. College of pharmacy, Seoul National University
• 1997 - 2003 : B.S. College of pharmacy, Seoul National University
• Mar 2017 – Present : Assistant Professor, College of Pharmacy, Chungbuk National University
• Mar 2015 – Feb 2017 : Research Professor, Konkuk University Glocal Campus
• Jan 2011 – Feb 2015 : Postdoctoral Researcher, Vanderbilt University Medical Center
• Mar 2009 – Dec 2010 : Postdoctoral Researcher, College of pharmacy, Seoul National University

 

Research Areas

1. Structural Studies on membrane & soluble proteins

   
   

   1.1 Caveolin 3
   

   1.2 CD44
   

2. Engineering of Antibody Drug
   

   
   

3. Structure based Drug Design
   

 

Selected Publications

1. KS Jo, JH Kim, KS Ryu, JS Kang, CY Wang, YS Lee, MD Seo, YH Lee, HS Won (2019) Unique Unfoldase/Aggregase Activity of a Molecular Chaperone Hsp33 in its Holding-Inactive State, Journal of Molecular Biology, 431, 1468-1480
2. KS Jo, KS Ryu, HW Yu, SN Lee, JH Kim, EH Kim, CY Wang, CG Kim, CG Kim, HS Won (2018) Structural assessment of the tetramerization domain and DNA-binding domain of CP2c, J. Kor. Magn. Reson, 22, 119-124
3. DW Sim, J Song, JH Kim, JK Lee, DY Chung, KS Jo, CG Kim, MD Seo, HC Kang, JC Paneng, YP Kim, HW Won (2018) Enhancing bacterial production of a recombinant cetuximab-Fab by partial humanization and its utility for drug conjugation, Process Biochemistry 69, 123-130
4. KS Jo, DW Sim, EH Kim, DH Kang, YB Ma, JH Kim*, HS Won*, (2018) Backbone NMR Assignments of a Putative p53-binding Domain of the Mitochondrial Hsp40, Tid1 J. Kor. Magn. Reson, 22, 64-70 (* co-corresponding authors)
5. JH Kim, H-S Won, WS Yoon, SH Seok, BJ Jung, SN Lee, DW Sim, MD Seo (2018) Crystal Structure of Shigella flexneri SF173 Reveals a Dimeric Helical Bundle Conformation, crystals 8(2) 97
6. DW Sim, Z Lu, HS Won, SN Lee, MD Seo, BJ Lee, JH Kim (2017) Application of Solution NMR to Structural Studies on α-Helical Integral Membrane Proteins, Molecules 22(8) E1347
7. DW Sim*, JW Choi*, JH Kim*, KS Ryu, M Kim, HW Yu, KS Jo, EH Kim, MD Seo, YH Jeon, BJ Lee, YP Kim, HS Won (2017) C-terminal dimerization of apo-cyclic AMP receptor protein validated in solution, FEBS letters 591(7), 1064-1070 (* co-first authors)
8. JH Kim, B Park (2017) Triptolide blocks the STAT3 signaling pathway through induction of protein tyrosine phosphatase SHP-1 in multiple myeloma cells, International Journal of Molecular Medicine 40, 1566-1572
9. SH Lee, DW Sim, EH Kim, JH Kim*, and HS Won* (2017) Backbone NMR Assignments and Secondary Structure Determination of a Cupin-family Protein YaiE from Escherichia coli, J. Kor. Magn. Reson, 21, 50-54 (* co-corresponding authors)
10. DW Sim*, JH Kim*, HY Kim*, JH Jang, WC Lee, EH Kim, PJ Park, KH Lee, HS Won (2016) Structural identification of the lipopolysaccharide‐binding capability of a cupin‐family protein from Helicobacter pylori, FEBS letters 590(17), 2997-3004 (* co-first authors)
11. JH Kim, DW Sim, DS Park, TG Jung, SH Lee, TH Oh, JR Ha, SH Seok, MD Seo, HC Kang, YP Kim, HS Won (2016) Bacterial production and structure-functional validation of a recombinant antigen-binding fragment (Fab) of an anti-cancer therapeutic antibody targeting epidermal growth factor receptor, Applied Microbiology and Biotechnology 100(24), 10521-10529
12. JH Kim, JP Schlebach, ZL D Peng, KC. Reasoner, CR. Sanders (2016) A pH-mediated topological switch within the N-terminal domain of human Caveolin-3, Biophysical Journal 110(11) 2475-2485
    
13. JP Schlebach ,PJ Barrett, CA Day, JH Kim, AK Kenworthy , CR Sanders (2016) Topologically diverse human membrane proteins partition to liquid-disordered domains in phase-separated lipid vesicles, Biochemistry 55(7) 985-8
    
14. JH Kim*, YC Kim*, B Park (2016) Hispolon from Phellinus linteus induces apoptosis and sensitizes human cancer cells to the tumor necrosis factor-related apoptosis-inducing ligand through upregulation of death receptors, Oncology Reports 35(2) 1020-6 (* co-first authors)
    
15. B Kim*, JH Kim*, B Park (2016) Pomolic acid inhibits invasion of breast cancer cells through the suppression of CXC chemokine receptor type 4 expression, J Cell Biochem 117(6) 1296-307 (* co-first authors)
    
16. DW Sim, YS Lee, MD Seo, HS Won, and JH Kim (2015) A simple guide to the structural study on membrane proteins in detergents using solution NMR, J. Kor. Magn. Reson, 19(3) 137-142
    
17. KY Lee, JH Kim, YJ Bae, and BJ Lee (2015) pH effect on the structure of reduced NifU–like protein from Helicobacter pylori, J. Kor. Magn. Reson, 19(3) 106-111
    
18. KY Lee, KY Lee, JH Kim, IG Lee, SH Lee, DW Sim, HS Won, BJ Lee (2015) Structure–based functional identification of Helicobacter pylori HP0268 as a nuclease with both DNA nicking and RNase activities, Nucleic Acids Research 43(10), 5194-207
    
19. IG Lee, SJ Lee, S Chae, KY Lee, JH Kim, and BJ Lee (2015) Structural and functional studies of the Mycobacterium tuberculosis VapBC30 toxin-antitoxin (TA) system: implications into the design of novel antimicrobial peptides, Nucleic Acids Research 43(15) 7624-37
    
20. CL Deatherage, Z Lu, JH Kim, and CR Sanders, (2015) Notch transmembrane domain: secondary structure and topology, Biochemistry 54(23) 3565-8
    
21. JH Kim, D Peng, JP Schlebach, A Hadziselimovic, CR Sanders, (2014) Modest effects of lipid modifications on the structure of Caveolin-3, Biochemistry 53(27) 4320-2,
    
22. D Peng, JH Kim, BM Kroncke, CL Law, Y Xia, KD Droege, WD Van Horn, CG Vanoye, CR Sanders, (2014) Purification and structural study of the voltage-sensor domain of the human KCNQ1 potassium ion channel, Biochemistry 53(12) 2032-42

Education & Career:

• 2005-2009: BS in Pharmacy, College of Pharmacy, Chungbuk National University, Cheongju, Republic of Korea.
• 2009-2011: MS in Pharmacy, College of Pharmacy, Chungbuk National University, Cheongju, Republic of Korea.
• 2011-2016: PhD in Pharmacy, College of Pharmacy, Chungbuk National University, Cheongju, Republic of Korea.
• 2016.3-2016.8: Research Fellow, College of Pharmacy, Chungbuk National University, Cheongju, Republic of Korea.
• 2016.10-2018.9: Research Fellow, Department of Molecular and Cell Biology, University of California, Berkeley, USA
• 2018.9-2022.8: Research Fellow, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, USA
• 2022.9~Present: Assistant Professor, College of Pharmacy, Chungbuk National University, Cheongju, Republic of Korea.

Research Areas

1. TCR signaling and T cell development
   The fate of developing T cells is determined by the strength of T cell receptor (TCR) signal they receive in the thymus. This process is finely regulated through tuning of positive and negative regulators in thymocytes. Recently, the Family with sequence similarity 49 member B (Fam49b) protein is discovered negative regulator of TCR signaling that has been shown to suppress Rac-1 activity in vitro in cultured T cell lines. However, the contribution of Fam49b to thymic development of T cells is unknown. In our lab, we are focusing on the effect of Fam49b on T cells developing, peripheral survival, and functional activity.
   
2. Obesity, inflammation, and the immune system
   Chronic inflammation plays a critical role in the development of obesity-associated metabolic disorders such as insulin resistance. Obesity alters the microenvironment of metabolic tissues such as adipose tissue and liver from anti-inflammatory to pro-inflammatory, which promotes low grade systemic inflammation and insulin resistance in obese mice. These inflammatory changes are important because they represent potential therapeutic targets in obesity-induced metabolic disorder as well as obesity. In our lab, we are focusing on the mechanism of obesity-induced systemic inflammation caused by intestinal immune cells and development of novel anti-obesity treatments.
   
3. Research on immuno-metabolism: Development of a novel anti-obesity drug
   
   

 

Education & Career

• 2005 - 2008 : Ph.D. in Pharmaceutics, Sungkyunkwan University, Suwon, South Korea.
• 2003 - 2005 : M.S. in Pharmaceutics, Sungkyunkwan University, Suwon, South Korea.
• 1997 - 2003 : B.S. in Pharmacy, Sungkyunkwan University, Suwon, South Korea.
• Sept 2012 – Present : Assistant Professor, College of Pharmacy, Chungbuk National University
• Nov 2011 – Aug 2012 : Research Associate, School of Pharmacy, Sungkyunkwan University
• May 2010 – Aug 2011: Visiting Postdoctoral Fellow, University of Kentucky College of Pharmacy
• Sept 2008 – Apr 2010 : Research Associate, School of Pharmacy, Sungkyunkwan University

Research Areas

1. Lung-targeted Dry Powder Inhalation (DPI)
   

   

2. Transdermal/Dermal-targeted formulation development
   

   

3. Microparticle engineering for pharmaceutical dosage forms
   

   

Selected Publications

1. Min Jeong Jo, Ik Sup Jin, Chun-Woong Park, Bang Yeon Hwang, Youn Bok Chung, Jin-Seok Kim, Dae Hwan Shin, Revolutionizing technologies of nanomicelles for combinatorial anticancer drug delivery, Archives of Pharmacal Research 43, 100–109 (2020)
2. Kyu-Mok Hwang, Thi-Tram Nguyen, Su Hyun Seok, Hyun-Il Jo, Cheol-Hee Cho, Kyu-Min Hwang, Ju-Young Kim, Chun-Woong Park, Yun-Seok Rhee, Eun-Seok Park, Swellable and porous bilayer tablet for gastroretentive drug delivery: Preparation and in vitro-in vivo evaluation, International journal of pharmaceutics 572, 118783 (2019)
   
3. Dong-Won Oh, Jinmann Chon, Min-Ju Na, Ji-Hyun Kang, Eun-Seok Park, Yun-Seok Rhee, Ju-Young Kim, Dae Hwan Shin, Dong-Wook Kim, Chung-Woong Park, Preparation and physicochemical characterization of rotigotine drug-in-adhesive patch containing crystal growth inhibitor, Journal of Drug Delivery Science and Technology 53, 101193 (2019)
   
4. Min Jeong Jo, Yang Hee Jo, Yu Jin Lee, Chun-Woong Park, Jin-Seok Kim, Jin Tae Hong, Youn Bok Chung, Mi Kyeong Lee, Dae Hwan Shin, Physicochemical, Pharmacokinetic, and Toxicity Evaluation of Methoxy Poly(ethylene glycol)-b-Poly(d,l-Lactide) Polymeric Micelles Encapsulating Alpinumisoflavone Extracted from Unripe Cudrania tricuspidata Fruit, Pharmaceutics 11(8), 366 (2019)
   
5. Ji-Hyun Kang, Jinmann Chon, Young-Il Kim, Hyo-Jung Lee, Dong-Won Oh, Hong-Goo Lee, Chang-Soo Han, Dong-Wook Kim, Chun-Woong Park, Preparation and evaluation of tacrolimus-loaded thermosensitive solid lipid nanoparticles for improved dermal distribution, International Journal of Nanomedicine 14, 5381-5396 (2019)
   
6. Hong-Goo Lee, Yun-Sang Park, Jin-Hyuk Jeong, Yong-Bin Kwon, Dae Hwan Shin, Ju-Young Kim, Yun-Seok Rhee, Eun-Seok Park, Dong-Wook Kim, Chun-Woong Park, Physicochemical properties and drug-release mechanisms of dual-release bilayer tablet containing mirabegron and fesoterodine fumarate, Drug design development and therapy 13, 2459 (2019)
   
7. Thi-Tram Nguyen, Eun-Jin Yi, Kyu-Mok Hwang, Cheol-Hee Cho, Chun-Woong Park, Ju-Young Kim, Yun-Seok Rhee, Eun-Seok Park, Formulation and evaluation of carrier-free dry powder inhaler containing sildenafil, Drug delivery and translational research 9 (1), 319-333 (2019)
   
8. Chang-Soo Han, Seungsu Kim, Dong-Won Oh, Jeong Yeol Yoon, Eun-Seok Park, Yun-Seok Rhee, Ju-Young Kim, Dae Hwan Shin, Dong-Wook Kim*, Chun-Woong Park*, Preparation, characterization, and stability evaluation of taste-masking lacosamide microparticles, Materials 12 (6), 1000 (2019)
9. Hyo-Jung Lee, In-Ho Kwon, Hong-Goo Lee, Yong-Bin Kwon, Hye-Min Woo, Sang-Min Cho, Youn-Woong Choi, Jinmann Chon, Kibum Kim, Dong-Wook Kim*, Chun-Woong Park*, Spiral mouthpiece design in a dry powder inhaler to improve aerosolization, International journal of pharmaceutics 553 (1-2), 149-156 (2018)
   
10. Ji-Hun An, Wonno Youn, Alice Kiyonga, Changjin Lim, Minho Park, Young-Ger Suh, Hyung Ryu, Jae Kim, Chun-Woong Park*, Kiwon Jung*, Kinetics of the Solution-Mediated Polymorphic Transformation of the Novel l-Carnitine Orotate Polymorph, Form-II, Pharmaceutics 10 (4), 171 (2018)
    
11. Hong-Goo Lee, Dong-Wook Kim, Chun-Woong Park, Dry powder inhaler for pulmonary drug delivery: human respiratory system, approved products and therapeutic equivalence guideline, Journal of Pharmaceutical Investigation 48 (6), 603-616 (2018)
    
12. Hyo-Jung Lee, Hong-Goo Lee, Yong-Bin Kwon, Ju-Young Kim, Yun-Seok Rhee, Jinmann Chon, Eun-Soek Park, Dong-Wook Kim*, Chun-Woong Park*, The role of lactose carrier on the powder behavior and aerodynamic performance of bosentan microparticles for dry powder inhalation, European Journal of Pharmaceutical Sciences 117, 279-289 (2018)
    
13. Hun Jun, Hyo-Jung Lee, Beom-Soo Shin, Chun-Woong Park, Preparation and in vivo characterization of dual release tablet containing sarpogrelate hydrochloride, Journal of Pharmaceutical Investigation 48 (3), 363-372 (2018)
    
14. Chun-Woong Park, Hyo-Jung Lee, Dong-Won Oh, Ji-Hyun Kang, Chang-Soo Han, Dong-Wook Kim, Preparation and in vitro/in vivo evaluation of PLGA microspheres containing norquetiapine for long-acting injection, Drug Design, Development and Therapy 12, 711-719 (2018)
15. Jung-Myung Ha, Jeong-Woong Seo, Su-Hyeon Kim, Ju-Young Kim, Chun-Woong Park, Yun-Seok Rhee, Eun-Seok Park, Implementation of quality by design for formulation of rebamipide gastro-retentive tablet, AAPS PharmSciTech 18 (8), 3129-3139 (2017)
    
16. Su-Hyeon Kim, Kyu-Min Hwang, Cheol-Hee Cho, Thi-Tram Nguyen, Su Hyun Seok, Kyu-Mok Hwang, Ju-Young Kim, Chun-Woong Park, Yun-Seok Rhee, Eun-Seok Park, Application of continuous twin screw granulation for the metformin hydrochloride extended release formulation, International journal of pharmaceutics 529 (1-2), 410-422 (2017)
    
17. Hyo-Jung Lee, Dong-Won Oh, Min-Ju Na, Dong-Wook Kim, Dong-Yeon Yuk, Hyoung-Chul Choi, Yong-Beom Lee, Kun Han*, Chun-Woong Park *, Preparation and in vivo evaluation of lecithin-based microparticles for topical delivery of minoxidil, Archives of pharmacal research 40 (8), 943-951 (2017) *Co-corresponding authors to this work
    
18. Dae Hwan Shin, So Young Lee, Sung Woo Jeong, Chun-Woong Park, Youn Bok Chung, Interspecies pharmacokinetic scaling of 11-hydroxyaclanomycin X based on animal data, Journal of Biomedical and Translational Research 18 (1), 24-29 (2017)
    
19. Dong-Won Oh, Ji-Hyun Kang, Hyo-Jung Lee, Sang-Duk Han, Min-Hyung Kang, Yie-Hyuk Kwon, Joon-Ho Jun, Dong-Wook Kim, Yun-Seok Rhee, Ju-Young Kim, Eun-Seok Park, Chun-Woong Park, Formulation and in vitro/in vivo evaluation of chitosan-based film forming gel containing ketoprofen, Drug delivery 24 (1), 1056-1066 (2017)
    
20. Hyo-Jung Lee, Ju-Young Kim, Sung-Hoon Park, Yun-Seok Rhee, Chun-Woong Park*, Eun-Seok Park*, Controlled-release oral dosage forms containing nimodipine solid dispersion and hydrophilic carriers, Journal of Drug Delivery Science and Technology 37(2), 28-37 (2017)

Patents

1. Delayed-release pharmaceutical composition containing n-desalkylquetiapine as active ingredient and a method for manufacturing the same, Korean Patent Number 10-1985838-0000 (2019)
   
2. System using refined tablets containing sand for remediating nitrate contaminated ground water, Korean Patent Number 10-1826756-0000 (2018)
   
3. System using refined tablets containing bentonite for remediating nitrate contaminated ground water, Korean Patent Number 10-1826755-0000 (2018)
   
4. Metformin extended-release tablets having enhanced patient compliance and its preparing method, Korean Patent Number 10-1910707-0000 (2018)
   
5. Stability improved composite particles containing fesoterodine fumarate and oral dosage form comprising the same, Korean Patent Number 10-1808963-0000 (2017)
   
6. Taste-masking composite particles containing donepezil freebase and oral dosage form comprising the same, Korean Patent Number 10-1791342-0000 (2017)
   
7. A pharmaceutical composition comprising minoxidil, Korean Patent Number 10-1766752-0000 (2017)

Industrial collaboration

1. Formulation of MNX liposomal product (2015; TOTAL HEALTH POINT)
2. Formulation of PMX fixed dose combination (2015; CRYSTALGENOMICS)
3. Formulation of DWJ133 extended-release oral dosage form (2013-2015; DAEWOONG PHARM)
4. Formulation of IT102 fixed-dose combination product (2015-2016; ITHENAPHARM)
5. Formulation of DNP orally disintegrating product (2015-2016; COREPHARM BIO)
6. Formulation of CLD / BZP topical gel (2015; HPNC)
7. Feasibility study of KTP film-forming gel (2016; DONG-A PHARM)
8. Formulation of TCR topical gel (2016; HPNC)
9. Feasibility study of iontophoresis system (2017; DONG-A PHARM)
10. PK-PD study of AFM/BUD fixed-dose DPI product (2017-2018; KOREA UNITED PHARM)
11. Optimization study of DPI device design (2017; KOREA UNITED PHARM)
12. Formulation of BST inhalable microparticles for DPI (2017-2018; MOTHERS PHARM)
13. Formulation of PRX transdermal patch (2017; JEIL HEALTH SCIENCE)
14. PD study of scar gel product (2018; DONG-A PHARM)
15. Formulation of ATB101 fixed-dose combination product (2017-2018; AUTOTELLICBIO)
16. Formulation of ATB102 fixed-dose combination product (2017-2018; AUTOTELLICBIO)
17. Physicochemical study of PLLA filler product (2018, PRP SCIENCE)
18. Formulation of MRB extended-release oral dosage form (2018; SHINIL PHARM)
19. Formulation of APX / RVX solubilized oral dosage form (2018; SHINIL PHARM)
20. Formulation of active coated suture product (2018; metaBIOMED)
21. Formulation of TCR solid lipid nanoparticle product (2018; AUTOTELLICBIO)
22. Formulation of GMG/DPG fixed-dose combination (2018; LG CHEM)
23. 16HBE14o Cell study of AFM/BUD fixed-dose DPI product (2018; KOREA UNITED PHARM)
24. Formulation of DNP microneedle patch product (2018; SMALL LAB)
25. Lung distribution of AFM/BUD fixed-dose DPI product (2019; KOREA UNITED PHARM)

Education & Career:

• 2023.03-Present Assistant professor, College of pharmacy, Chungbuk national university
• 2020.09-2023.02 Research Assistant professor, Dept. of Chemistry, Dongguk university
• 2020.03-2020.08 Postdoctoral Fellow, Dept. of Chemistry, Dongguk university
• 2015.03-2020.02 Dept. of Biomedical engineering, Dongguk university. PhD
• 2012.03-2014.08 Dept. of Applied life science, Gyeongsang national university. M.S
• 2008.03-2012.02 Dept. of Animal science, Gyeongsang national university. B.S

Research Areas

1. CRISPR-mediated Gene Therapy
   The clustered regularly interspaced short palindromic repeat (CRISPR)/Cas9 system has emerged as a powerful method for gene inactivation via the formation of small insertions/deletions (indels) and for specific genome editing by dramatically increasing the efficiency of homology-directed repair. The speed and ease of CRISPR/Cas9-mediated gene editing make it an ideal platform for optimizing in vivo disease correction. The ultimate goal of our laboratory is to develop new treatments for various human diseases through genome editing. Finally, we hope to provide the key to combating previously incurable diseases through gene therapy.
2. Stem cell-based Cell Therapy
   Stem cell-based cell therapy is an important field of regenerative medicine with the ultimate goal of enhancing the repair machinery. Our study is based on induced pluripotent stem cells (iPSCs) and direct conversion providing convincing evidence that autologous cell replacement therapies can treat various disorders. To this end, our lab develops innovative cell therapy methods for clinical applications and possible solutions to incurable disease.

 

Selected Publications

1. Hanseul Park#, Byounggook Cho#, Hongwon Kim, Takashi Saito, Takaomi C Saido, Kyoung-Jae Won, Jongpil Kim. Single-cell RNA-sequencing identifies disease-associated oligodendrocytes in male APP NL-G-F and 5XFAD mice. Nature communications. 2023 Feb 13. IF17.694, 7.432%
2. Hanseul Park#, Jaein Shin#, Yunkyung Kim, Takashi Saito, Takaomi C Saido, Jongpil Kim. CRISPR/dCas9-Dnmt3a-mediated targeted DNA methylation of APP rescues brain pathology in a mouse model of Alzheimer's disease. Translational Neurodegeneration. 2022 Sep. IF9.883, 7.818%
3. Hongwon Kim#, Byounggook Cho#, Hanseul Park#, Junyeop Kim, Siyoung Kim, Jaein Shin, Christopher J Lengner, Kyoung-Jae Won, Jongpil Kim. Dormant state of quiescent neural stem cells links Shank3 mutation to autism development. Molecular Psychiatry. 2022 Jun. IF13.437, 4.545%
4. Hanseul Park, Jongpil Kim. Activation of melatonin receptor 1 by CRISPR-Cas9 activator ameliorates cognitive deficits in an Alzheimer's disease mouse model. Journal of Pineal Research. 2022 Apr. IF12.081, 3.086%
5. Hanseul Park, Dongyoon Kim, Byounggook Cho, Junho Byun, Yong Sook Kim, Youngkeun Ahn, Jin Hur, Yu-Kyoung Oh, Jongpil Kim. In vivo therapeutic genome editing via CRISPR/Cas9 magnetoplexes for myocardial infarction. Biomaterials. 2022 Feb. IF15.863, 2.551%
6. Hanseul Park, Yerim Hwang, Jongpil Kim. Transcriptional activation with Cas9 activator nanocomplexes rescues Alzheimer's disease pathology. Biomaterials. 2021 Dec. IF15.863, 2.551%
7. Hanseul Park, Byounggook Cho, Jongpil Kim. Rad50 mediates DNA demethylation to establish pluripotent reprogramming. Experimental and Molecular Medicine. 2020 Jul. IF12.172, 6.902%
8. Hanseul Park, Jungju Oh, Gayong Shim, Byounggook Cho, Yujung Chang, Siyoung Kim, Soonbong Baek, Hongwon Kim, Jeain Shin, Hwan Choi, Junsang Yoo, Junyeop Kim, Won Jun, Minhyung Lee, Christopher J Lengner, Yu-Kyoung Oh, Jongpil Kim. In vivo neuronal gene editing via CRISPR-Cas9 amphiphilic nanocomplexes alleviates deficits in mouse models of Alzheimer's disease. Nature Neuroscience. 2019 Apr. IF28.771, 0.545%
9. Hanseul Park, Hongwon Kim, Junsang Yoo, Jaekwang Lee, Hwan Choi, Soonbong Baek, C Justin Lee, Janghwan Kim, Christopher J Lengner, Jung-Suk Sung, Jongpil Kim. Homogeneous generation of iDA neurons with high similarity to bona fide DA neurons using a drug inducible system. Biomaterials. 2015 Dec.  IF15.863, 2.551%

Education & Career :

• 1986 B.S. College of Pharmacy, Chungbuk University, Korea
  
• 1989 M.S. Korea Advanced Institute of Science and Technology
  
• 1998 Ph.D. Korea Advanced Institute of Science and Technology
  
• 1998-2001 Visiting Scientist. National Cancer Institute, NIH
• 2005-2007 Assistant Dean, Collage of Pharmacy

Research Areas

1. Cell Division Cycle, Polo-like kinase
   
2. Cancer Development, Modulation of Cell Proliferation
   
3. Genome Stability, Spindle Checkpoint

 

Selected Publications

1. Lung tumor growth-promoting function of peroxiredoxin 6, FREE RADICAL BIOLOGY AND MEDICINE, 2013
2. Downregulation of Melanocyte-Specific Facultative Melanogenesis by 4-Hydroxy-3-Methoxycinnamaldehyde Acting as a cAMP Antagonist, JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2014
3. Baccatin III, a precursor for the semisynthesis of paclitaxel, inhibits the accumulation and suppressive activity of myeloid-derived suppressor cells in tumor-bearing mice, INTERNATIONAL IMMUNOPHARMACOLOGY, 2014
4. Resiquimod, a TLR7/8 agonist, promotes differentiation of myeloid-derived suppressor cells into macrophages and dendritic cells, ARCHIVES OF PHARMACAL RESEARCH, 2014
5. Identification of HLA-A2-restricted immunogenic peptides derived from a xenogenic porcine major histocompatibility complex, XENOTRANSPLANTATION, 2014
6. Suberoylanilide hydroxamic acid induces ROS-mediated cleavage of HSP90 in leukemia cells, CELL STRESS & CHAPERONES, 2015
7. Interleukin-32 gamma attenuates ethanol-induced liver injury by the inhibition of cytochrome P450 2E1 e-pression and inflammatory responses, CLINICAL SCIENCE, 2015
8. Decreased severity of collagen antibody and lipopolysaccharide-induced arthritis in human IL-32β overexpressed transgenic mice., Oncotarget, 2015
9. Minocycline promotes the generation of dendritic cells with regulatory properties, ONCOTARGET, 2016
10. Tolerogenic dendritic cells are efficiently generated using minocycline and dexamethasone, SCIENTIFIC REPORTS, 2017

Education

• 2001-2005    B.S. College of Pharmacy, Chungbuk National University, Republic of Korea.
  
• 2005-2007    M.S. Department of Pharmaceutics, College of Pharmacy, Chungbuk National University, Republic of Korea.
  
• 2007-2012    Ph.D. Department of Pharmaceutics, College of Pharmacy, Chungbuk National University, Republic of Korea.
  

Career

• 2012~2015     Research Fellow, Research Center for Cell Fate Control (RCCFC) & College of Pharmacy, Sookmyung Women’s University, Seoul 04310, Republic of Korea.
  
• 2015~2017     Research Associate, Pharmaceutical Science Division, School of Pharmacy, University of Wisconsin-Madison, WI 53705-2222 USA.
  
• 2017~2018     Assistant Professor, College of Pharmacy and Natural Medicine Research Institute, Mokpo National University, Jeonnam 58554, Republic of Korea.
  
• 2019~2020     Visiting Researcher, Institute for Bioengineering of Catalonia (IBEC), Barcelona, Spain
  
• 2024~2025     Visiting Professor, Universitat Politècnica de València (UPV), Valencia, Spain
• 2018~present  Assistant Professor, College of Pharmacy, Chungbuk National University, Cheongju 28160, Republic of Korea.
• 2021~present  CEO, Korea Animal Replacement Experiment (KARE), Cheongju 28160, Republic of Korea.
  http://www.kare.re.kr/

Research Areas

1. Systemic drug delivery system (micelle, liposome)






2. Local drug delivery system (thermosensitive gel: thermogel)



3. Targeting cancer stem cells



4. Pharmacokinetics and pharmacodynamics (PK/PD)



5. 5. Interspecies scaling & human parameter prediction



6. Vascular normalization for drug delivery



7. Animal replacement experiment techniques

 

 

Selected Publications

1. Gemcitabine and rapamycin-loaded mixed polymeric thermogel for metastatic pancreatic cancer therapy, Seo Yeon Kim, Min Jeong Jo, Moon Sup Yoon, Chae Eun Jin, Yu Been Shin, Jae Min Lee, Hee Ji Shin, Joon Gyo Oh, Jae Min Cho, Hyunjun Kim, Hyunjin Park, Yong-Won Choi, Chun-Woong Park, Jin-Seok Kim, and Dae Hwan Shin*, J. Control. Release (2023)
2. Yu Been Shin, Ju-Yeon Choi, Dae Hwan Shin*, Jeong-Won Lee*, Anticancer evaluation of methoxy poly(ethylene glycol)-b-poly(caprolactone) polymeric micelles encapsulating fenbendazole and rapamycin in ovarian cancer, Int. J. Nanomed. (2023)
3. Min Jeong Jo, Hee Ji Shin, Moon Sup Yoon, Seo Yeon Kim, Chae Eun Jin, Chun-Woong Park, Jin-Seok Kim, and Dae Hwan Shin*, Evaluation of pH-Sensitive Polymeric Micelles Using Citraconic Amide Bonds for the Co-Delivery of Paclitaxel, Etoposide, and Rapamycin, Pharmaceutics (2023)
4. Hee Ji Shin, Min Jeong Jo, Ik Sup Jin, Chun-Woong Park, Jin-Seok Kim, Dae Hwan Shin*, Optimization and Pharmacokinetic Evaluation of Synergistic Fenbendazole and Rapamycin Co-Encapsulated in Methoxy Poly(Ethylene Glycol)-b-Poly(Caprolactone) Polymeric Micelles, Int. J. Nanomed. (2021)
5. Jeong Hyun Shin, Jin‑Seok Kim, Dae Hwan Shin*, Let-7 miRNA and CDK4 siRNA co-encapsulated in Herceptin-conjugated liposome for breast cancer stem cells, Asian J. Pharm. Sci. (2020)

Selected Patents

1. albumin nanoparticles containing docetaxel and afatinib, and uses thereof, Korean Patent Number 10-2576559 (2023)
2. Polyethylene glycol-polycaprolactone copolymer micelles containing docetaxel and osthol, and uses thereof, Korean Patent Number 10-2490940 (2023)
3. A Composition for Solubilizing Fenbendazole and Uses Thereof, Korean Patent Number 10-2455423 (2022)
4. A Composition for Solubilizing Fingolimod derivative compound and Uses Thereof, Korean Patent Number 10-2377334 (2022)
5. A Composition for Solubilizing Alpinumisoflavone and Uses Thereof, Korean Patent Number 10-2021-0083485 (2021)

Lab of Pharmaceutics

Education & Career

• 2001 Osaka University PhD in Macromolecular Science
• 1999 Osaka University MS in Macromolecular Science
• 1989 Seoul National University BS in Pharmacy
• 1989 – 1996 ChungWae Pharm. Co., Senior Scientist
• 2002 - 2004 Osaka University, Post-doctoral fellow (Department of Medicine)
• 2004 - 2006 MRC-LMB, Cambridge, UK, Post-doctoral fellow (Structural Studies)
• 2006 - present Chungbuk National University, Professor (Department of Manufacturing Pharmacy)
• 2007 - 2009 Chairman, Department of Manufacturing Pharmacy
• 2017 - 2019 Deputy Dean, College of Pharmacy

Honor and Awards

• 1996 - 2001 Japanese Government Scholorship(Monbusho Scholarship)
• 2002 - 2004 JSPS Postdoctoral Fellowship for Foreign Researchers
• 2004 - 2006 EMBO Fellowship

 

Research Areas

Our group at Chungbuk National University has been focused on the elucidation of structure-function relationship of protein-protein or protein-RNA complexes, especially nuclear transport related protein complexes including importin- family. A eukaryotic cell is divided into two major compartments, nucleus and cytoplasm by nuclear envelope. Intracellular signals are transmitted via the continuous and bi-directional transport of proteins between the nucleus and the cytoplasm through nuclear pores. To elucidate the molecular basis for such intracellular communication in atomic level, we crystallize and solve the structure of nuclear-transport carrier proteins.

Recently, we expanded our research interests with protein drugs including antibody. Collaboration with Osong KBIO for the X-ray structural analysis of virus antibody-antigen complex are in progress.

 

 

Selected Publications

1. Yamazawa R., Jiko C., Choi S., Park I.Y., Nakagawa A., Yamashita E. a, Lee S.J. a, (2018) Structural Basis for Selective Binding of Export Cargoes by Exportin-5. Structure 2018 Oct 2;26(10):1393-1398 ( a corresponding author)
2. Song J., Kose S. a, Watanabe A., Son S.Y., Choi S., Hong H., Yamashita E., Park IY., Imamoto N. a, Lee S.J. a (2015) Structural and functional analysis of Hikeshi, a new nuclear transport receptor of Hsp70s. Acta Crystallogr D Biol Crystallogr. 2015 Mar 1;71(Pt 3):473-83. ( a corresponding author)
3. Choi S., Yamashita E., Yasuhara N., Song J., Son S.Y., Won Y.H., Hong H.R., Shin Y.S., Sekimoto T., Park I.Y., Yoneda Y. a, Lee S.J. a (2014) Structural basis for the selective nuclear import of the C2H2 zinc-finger protein Snail by importin β. Acta Crystallogr D Biol Crystallogr. 2014 Apr;70(Pt 4):1050-60. ( a corresponding author)
4. Wyszynski FJ, Lee SS, Yabe T, Wang H, Gomez-Escribano JP, Bibb MJ, Lee SJ, Davies GJ, Davis BG.(2012) Biosynthesis of the tunicamycin antibiotics proceeds via unique exo-glycal intermediates. Nature Chemistry 4, 7, 539-546
5. Lee S.J a, Jiko C, Yamashita E, Tsukihara T a.(2011) Selective nuclear export mechanism of small RNAs. Curr. Opi. Struct. Biol. 21, 1, 101-108 (a corresponding author)
6. Okada C*., Yamashita E*., Lee S.J*,a., Shibata S., Katahira J., Nakagawa A., Yoneda Ya., Tsukihara Ta. A high-resolution structure of the pre-microRNA nuclear export machinery Science 27, 326, 1275-1279 ( * equally contributed author,  a corresponding author )
7. Lee S.J., Ogasahara K., Ma J., Nishio K., Ishida M., Yamagata Y., Tsukihara T., Yutani K. (2005) Conformational Changes in the Tryptophan Synthase from a Hyperthermophile upon a2b2 Complex Formation : Crystal Structure of the Complex Biochemistry 44, 11417-11427
8. Lee S.J., Matsuura Y., Liu S.M., Stewart M. (2005) Structural basis for nuclear import complex dissociation by RanGTP. Nature 435, 7042, 693-696.
9. Tsunehiro M., Takeshi H., Yukiko Y., Lee S.J., Tomoki C., Kazuhiro I, Yoshiki Y., Koichi K., Tomitake T., Keiji T. (2004) Structural basis of sugar-recognizing ubiquitin ligase. Nat. Struc. Mol. Biol., 11, 365-370.
10. Lee S.J., Sekimoto T., Yamashita E., Nagoshi E., Nakagawa A., Sakai H., Imamoto N., Tsukihara T., Yoneda Y. (2003) The structure of importin-beta bound to SREBP-2: nuclear import of a transcription factor. Science. 302, 1571-1575.

Education & Career

• 1982 B.S. Callege of pharmacy, Seoul National University, Korea
  
• 1985 M.S. Callege of pharmacy, Seoul National University, Korea
  
• 1989 Ph.D. Callege of pharmacy, University of Tokyo, Japan
  
• 1994 Guest Researcher Nathional Cancer Institute, NIH, U.S.A
• 2007-2009 Dean, Collage of Pharmacy

Research Areas

1. Functional Analysis of Sphingolipid metabolites
   
2. Regulation and Evaluation of Life-style Disease by S1P

 

 

Selected Publications

1. Development and validation of rapid and simultaneous method for determination of 12 hair-growth compounds in adulterated products by UHPLC-MS/MS. Park HN, Lee JH, Park SK, Baek SY, Lee YM, Kang H. Forensic Sci Int. 2018 Mar;284:129-135.
2. Cellular and metabolic Basis for the Ichthyotic Phenotype in NIPAL4 (Ichthyin)-Deficient Canines. Mauldin EA, Crumrine D, Casal ML, Jeong S, Opálka L, Vavrova K, Uchida Y, Park K, Craiglow B, Choate KA, Shin KO, Lee YM, Grove GL, Wakefield JS, Khnykin D, Elias PM. Am J Pathol. 2018 Jun;188(6):1419-1429.
3. The effect of sphingosine-1-phosphate on bone metabolism in humans depends on its plasma/bone marrow gradient. Kim BJ, Shin KO, Kim H, Ahn SH, Lee SH, Seo CH, Byun SE, Chang JS, Koh JM, Lee YM. J Endocrinol Invest. 2016 Mar;39(3):297-303.
4. ER stress stimulates production of the key antimicrobial peptide, cathelicidin, by forming a previously unidentified intracellular S1P signaling complex. Park K, Ikushiro H, Seo HS, Shin KO, Kim YI, Kim JY, Lee YM, Yano T, Holleran WM, Elias P, Uchida Y. Proc Natl Acad Sci U S A. 2016 Mar 8;113(10):E1334-42.

Education & Career

• 2017: Pharm.D., College of Pharmacy, Korea University
• 2022: Ph.D. in Pharmaceutical Sciences, School of Pharmacy, University of Wisconsin-Madison, Madison, WI, USA
• 2023-2024: Postdoctoral Research Fellow, College of Pharmacy, University of Michigan, Ann Arbor, MI, USA
• 2024-present: Assistant Professor, College of Pharmacy, Chungbuk National University

Research Areas

1. Peptide and antibody drug delivery system
2. Antibody drug conjugates
3. Biopharmaceutical formulation
4. Molecular imaging

 

Selected Publications

1. Hye Jin Lee *, Ksenija Bernau*, Thomas J. Harr, Zachary T. Rosenkrans, Grace A. Kessler, Kristen Stott, Angie Tebon Oler, Babita Rahar, Terry Zhu, Yadira Medina-Guevara, Nikesh Gupta, Inyoung Cho, Metti K. Gari, Brian M. Burkel, Justin J. Jeffery, Ashley M. Weichmann, Bianca R. Tomasini-Johansson, Suzanne M. Ponik, Jonathan W. Engle, Reinier Hernandez, Glen S. Kwon, Nathan Sandbo. [⁶⁴Cu]Cu-PEG-FUD peptide for non-invasive and sensitive detection of murine pulmonary fibrosis. Science Advances, 2024, 12:10(15): eadj1444. *Co-first authors.
2. Hye Jin Lee, Bianca R. Tomasini-Johansson, Nikesh Gupta, and Glen S. Kwon. Fibronectin-targeted FUD and PEGylated FUD Peptides for Fibrotic Diseases. J. Control. Release, 2023, 360:69-81
3. Libor Kostka, Lenka Kotrchova, Eva Randarova, Carolina A. Ferreira, Iva Malatova, Hye Jin Lee, Aeli P. Olson, Jonathan W. Engle, Marek Kovař, Weibo Cai, Milada Šírová, and Tomaš Etrych. Evaluation of linear versus star-like polymer anti-cancer nanomedicines in mouse models. J. Control. Release, 2023, 353:549-562
4. Hye Jin Lee, Metti K. Gari, David R. Inman, Zachary T. Rosenkrans, Brian M. Burkel, Aeli P. Olson, Jonathan W. Engle, Reinier Hernandez, Suzanne M. Ponik, and Glen S. Kwon. Multimodal imaging demonstrates enhanced tumor exposure of PEGylated FUD peptide in breast cancer. J. Control. Release, 2022, 350: 284-297
5. Morteza Rasoulianboroujeni, Lauren Repp, Hye Jin Lee, and Glen S. Kwon. Production of paclitaxel-loaded PEG-b-PLA micelles using PEG for drug loading and freeze-drying. J. Control. Release, 2022, 350:350-359
6. Lauren Repp, Morteza Rasoulianboroujeni, Hye Jin Lee, and Glen S. Kwon. Acyl and oligo(lactic acid) prodrugs for PEG-b-PLA and PEG-b-PCL nano-assemblies for injection. J Control Release, 2020, 330:1004-1015.
7. Weijun Wei, Dawei Jiang, Hye Jin Lee, Jonathan W. Engle, Hisaya Akiba, Jianjun Liu, and Weibo Cai. ImmunoPET imaging of TIM-3 in murine melanoma models. Adv. Therap., 2020, 3(7):2000018
8. Weijun Wei, Dawei Jiang, Hye Jin Lee, Miao Li, Christopher J. Kutyreff, Jonathan W. Engle, Jianjun Liu, and Weibo Cai. Development and characterization of CD54-targeted immunoPET imaging in solid tumors. Eur. J. Nucl. Med. Mol. Imaging, 2020, 47(12):2765-2775
9. Libor Kostka, Lenka Kotrchová, Vladimir Subr, Alena Libánska, Carolina A. Ferreira, Iva Malatova, Hye Jin Lee, Todd E. Barnhart, Jonathan W. Engle, Weibo Cai, Milada Šírová, and Tomáš Etrych. HPMA-based star polymer biomaterials with tuneable structure and biodegradability tailored for advanced drug delivery to solid tumours. Biomaterials, 2020, 235:119728

Education & Career

• -

Patents

-

Patents

-

Education & Career

• 1988-1992: BS, College of Pharmacy, Seoul National University
  
• 1992-1994: MS, Synthetic Medicinal Chemistry, Seoul National University
  
• 1994-1999: Ph.D, Synthetic Medicinal Chemistry, Seoul National University
  
• 1999-2002: Post Doc. Research Center for New Drug Development, Seoul National University
  
• 2002-2003: Post Doc. Dept. of Chemistry, Boston College
  
• 2007-present: Professor, College of Pharmacy, Chungbuk National University
  
• 2009-2011: Chaiman, Dept. of Manufacturing Pharmacy, College of Pharmacy, Chungbuk National University
  
• 2007-2008: Visiting Professor, Dept. of Chemistry, Boston College
  
• 2017-present: Review Board, National Research Foundation (NRF)
  
• 2017-present: Associate Editor, Archives of Pharmacal Research (APR)
  
• 2015-present: Academic vice chairman of the Committee, Pharmaceutical Society of Korea (PSK)

Research Areas

1. Total Synthesis of Natural Product
   천연물 전합성(Total synthesis)은 간단한 출발 물질(Starting compound)로부터 유기화학 방법론을 활용하여 천연물을 합성하는 기술이다. 천연물로부터 신약을 개발하기 위해서는 분자구조와 생리활성 관계(Structure-Activity Relationship)를 검색하는 과정과 최종 목표화합물을 저비용으로 대량 합성할 수 있는 효율적인 과정의 개발이 필요하다. 이러한 과정에서 천연물의 효율적 전합성 기술과 응용이 필수적인 역할을 하게 된다. 실험실에서 이루어진 최근 연구결과, 다양한 구조를 가지는 천연물 전합성을 완료하였다. 대표적인 예로서는 Chloropeptin I, Fluvirucinine A1, (+)-Brefeldin A, (S)-Rodgersinol, Obovatol 등이 있다. 이들 천연물들은 독특한 구조적 특징 및 흥미로운 생리활성을 가지고 있으며, 전합성을 위하여 새로운 합성전략의 수립과 도출된 문제의 해결 등을 통하여 성공적으로 전합성을 완료하였다. 현재 Methyl Honokiol, Tetrabenazine 등의 천연물을 전합성 중에 있다. 천연물 전합성 능력/기술은 다양한 구조의 천연물 유도체의 합성에 활용될 수 있다.
   
   
2. Medicinal Chemistry & Drug Discovery
   세계적 신약개발 현황은 치료질병의 표적분자의 구조 및 약리작용단 (pharmacophore)을 기초로 한 합리적 약물설계 (rational drug design)에 의해 주로 진행 되고 있다. 합리적 약물설계를 위해서는 표적분자의 구조분석, 컴퓨터 분자모델링, 약리작용단의 분석 등의 의약화학적 신기술이 요구된다. 이러한 합리적 약물설계 기술을 이용하여 최근 항암제, 혈과평활근 증식 저해제, 치매치료제 등을 포함한 다수의 신약 선도물질을 개발하고 있다.  

Selected Publications

(Update 22.09.01)

1. Vishwanath, M.; Chaudhary, C. L.; Park. Y.; Viji, M.; Jung, C.; Lee, K.; Sim, J.; Hong, S. M.; Yoon, D. H.; Lee, D. H.; Lee, J. K.; Lee, H.; Kim, S. Y.*; Jung, J.-K.* Total Synthesis of Isohericerinol A and Its Analogs to Access Their Potential Neurotrophic Effects. J. Org. Chem. 2022, 87, 10836-10847. (IF = 4.354)
2. Jung, C.; Li, S.; Lee, K.; Viji, M.; Lee, H.; Hyun, S.; Lee, K.; Kang Y. K.; Chaudhary, C. L.; Jung, J.-K.* Reagent-free intramolecular hydrofunctionalization: a regioselective 6-endo-digcyclization of o-alkynoylphenols. Green Chem. 2022, 24, 2376-2384 (Mar 21) (IF=11.034)
3. Sim, J.; Srnu, L; Jo, J.; Chaudhary, C. L.; Vishwanath, M.; Jung, C.; Lee, Y. H.; Kim, E.-y.; Kim, Y.; Hyun, S.; Lee, H.; Lee, K.; Seo, S.-Y.; Viji, M.; Jung, J.-K.* Inhibitory effect of Chlorogenic acid derivatives comprising pyridine and pyrimidine on α-MSH-stimulated melanogenesis and stability of acyl CGA derivatives in methanol.Pharmaceuticals,2021, 14(11), 1176 (Nov 17) (IF=5.863)
4. Viji, M.; Srnu, L.;. Sim, J.; Jung, C.; Lee, H.; Vishwanath, M.; Jung, J.-K.* Regiodivergent Organocatalytic reactions. Catalysts, 2021, 8, 1013(Aug 22) (IF=4.501))
5. Viji, M.;  Vishwanath, M.; Sim, J.; Lee, S.; Park, Y.; Jung, C.: Lee H.; Lee, K.; Jung, J.-K.* α-Hydroxy acid as an aldehyde surrogate: metal-free synthesis of pyrrolo[1,2-a]quinoxalines, quinazolinones, and other N-heterocycles via decarboxylative oxidative annulation reaction RSC Adv. 2020, 10,37202-37208(Oct 7) (IF=4.036)
6. Sim, J.; Viji, M.; Rhee, J.; Jo H.; S.J. Cho.; Park, Y.; S.-Y. Seo.; K.-Y. Jung.; Lee, H.; Jung J.-K.* g-Functionalization of a,b-unsaturated nitriles under mild conditions: Versatile Synthesis of 4-Aryl-2-Bromopyridines. Adv. Synth. Catal. 2019, 361, 5458-5465 (IF = 5.981)(Selected as a VIP and Cover Page of ASC volume 23)(Dec 3)
7. Lee, S.; Sim, J.; Jo H.; Viji, M; Srinu, L.; Lee, K.; Lee, H.; Vishwanath, M.*; Jung J.-K.* Transition metal-Free Synthesis of Quinazolinones Using Dmethyl Sulfoxide as a Synthon. Org. Biomol. Chem. 2019, 17, 8067-8070 (IF=3.890) (Sep 21)
8. Lee Y. H.; Vishwanath, M.; Srinu, L; Lee, E.; Park, Y.; Lee, S.; Sim, J.; Lee, S.; Lee, K.; Viji, M.*; Lee, H.; Jung, J.-K.* Synthesis and Spectral Characterization of Impurities of a COX-2 Selective Drug, Celecoxib. Bull. Korean Chem. Soc. 2019, 40, 479-480 (Jun 28) (IF=1.241)
9. Viji, M; Sim J.; Li, S.; Lee, H.; Oh, K.; Jung J.-K.* Organocatalytic and Regiodivergent Mannich Reaction of Ketones with Benzoxazinones. Adv. Synth. Catal. 2018, 360, 4464-4469(Dec 3) (IF = 5.981)
10. Choi, M.; Viji, M.; Kim, D.; Lee, Y. H.; Sim, J.; Kwak, Y.-S.; Lee, H.; Jung, J.-K.*; metal-free approach for the ʟ-Proline Mediated Synthesis of Nitrones from Nitrosobenzene. Tetrahedron, 2018, 74, 4182-4187 (Aug 2) (IF = 2.457)
11. Jo, M.; Won, S.-W.; Lee, D. G.; Jung, J.-K.*; Kim, S.; Kwak, Y.-S*. An efficient synthetic protocol for amide derivatives of Boc-aminoisobutyrate. Arch. Pharm. Res. 2018, 41, 259-264 (Mar 30) (IF= 4.310)
12. Sim, J.; Jo H.; Viji, M; Choi, M.; Jung, J.; Lee, H.; Jung J.-K.* Rapid, operationally simple, and metal-free NBS mediated one pot synthesis of 1,2 naphthoquinone from 2-naphthol. Adv. Synth. Catal. 2018, 360, 852-858 (Mar 1) (IF = 5.981)
13. Jo, H.; Zhoi, Y.; Viji, M.; Choi, M.; Lim, J. Y.; Sim, J.; Rhee, J.; Kim, Y.; Seo, S.-Y.; Kim, W.J.; Hong, J. T.; Lee, H.; Lee, K.; Jung, J.-K.* Synthesis, Biological Evaluation, and metabolic Stability of Chlorogenic Acid Derivatives Possessing Thiazole as Potent Inhibitors of α-MSH-stimulated Melanogenesis. Bioorg. Med. Chem. Lett.2017, 27, 4854-4857 (Nov 1) (IF = 2.940)
14. Jo, H.; Choi, M.;  Sim, J.; Viji, M.; Li, S.; Lee, Y. H.; Kim, Y.; Seo, S.-Y.*; Zhou, Y.; Lee, K.; Kim, W.-J.; Hong, J. T.; Lee, H.; Jung, J.-K.* Synthesis and Biological Evaluation of Caffeic Acid Derivatives as Potent Inhibitors of α-MSH-stimulated Melanogenesis. Bioorg. Med. Chem. Lett.2017, 27, 3374-3377. (Aug 1) (IF = 2.940)
15. Lee, Y. H.; Viji, M.; Lee, E.; Jo, H.; Yoo, K.; Sim, J.; Lee, S.; Lee, K.; Lee, H.; Jung, J.-K.* Synthesis and characterization of Rosuvastatin calcium impurity A; a HMG-CoA Reductase Inhibitor. Tetrahedron Lett., 2017,58, 2614-2617. (Jun 28). (IF = 2.032)
16. Li, S.; Jin, F.; Viji, M.; Jo, H.; Sim, J.; Kim, H. S.*; Lee, H.; Jung, J.-K.* A novel cyclization/ oxidation strategy for two-step synthesis of (Z)-aurone. Tetrahedron Lett. 2017, 58, 1417-1420 (Mar 17) (IF = 2.032)
17. Hongbo, D.; Jung, J.-K.; Tao, L.; Kuntz, K.W.; Snapper, M. L.; Hoveyda, A. H. Total Synthesis of Anti-HIV Agent Chloropeptin I. J. Am. Chem., Soc. 2003, 125, 9032. (IF = 15.419)
18. Suh, Y.-G.; Kim, S.-A.; Jung, J.-K.; Shin, D.-Y.; Min, K.-H.; Koo, B.-A.; Kim, H.-S. Asymmetric Total Synthesis of Fluvirucinine A1. Angew. Chem. Int. Ed. Engl. 1999, 38, 3545. (IF = 15.336)

Education & Career:

• 1994-1998: BS in Pharmacy, College of Pharmacy, Seoul National University
• 1998-2000: MS in Pharmacy, Synthetic Medicinal Chemistry, Seoul National University
• 2001-2003: MS in Chemistry, Bioorganic Chemistry, Massachusetts Institute of Technology
• 2006-2010: PhD in Chemistry & Education, Chemical Biology, Seoul National University
• 2010-2011: Post Doc. Korea Research Institute of Bioscience & BioTechnology
• 2011-2014: Post Doc. Dept. of Chemistry & Education, Seoul National University
• 2014-2020: Research Assistant Professor, The Institute of Molecular Biology & Genetics, Seoul National University
• 2020-2021: Research Professor, College of Pharmacy, Gachon University
• 2021-present: Assistant Professor, College of Pharmacy, Chungbuk National University

Research Areas

1. Protein-protein interaction inhibitor 개발
2. Peptide drug 개발
3. Amphiphilic peptide mechanism of function 연구: Peptide-membrane interaction
   
4. Autophagy 기반 표적 단백질 분해 리간드 도출 및 이를 이용한 신약개발

 

Selected Publications

1. Hyun, S. #; Park, N.#; Nam, S. H.; Cheon, D. H.; Lee, Y.; Lim, H. S.; Yu, J., One-bead-one-compound screening approach to the identification of cyclic peptoid inhibitors of cyclophilin D as neuroprotective agents from mitochondrial dysfunction. Chem. Commun. 2021, 57 (19), 2388-2391. #co-first author
2. Hyun, S. #; Choi, Y. #; Jo, D.; Choo, S.; Park, T. W.; Park, S. J.; Kim, S.; Lee, S.; Park, S.; Jin, S. M.; Cheon, D. H.; Yoo, W.; Arya, R.; Chong, Y. P.; Kim, K. K.; Kim, Y. S.; Lee, Y.; Yu, J., Proline Hinged Amphipathic α-Helical Peptide Sensitizes Gram-Negative Bacteria to Various Gram-Positive Antibiotics. J. Med. Chem. 2020, 63 (23), 14937-14950. #co-first author
3. Hyun, S.;  Li, L.;  Yoon, K. C.; Yu, J., An amphipathic cell penetrating peptide aids cell penetration of cyclosporin A and increases its therapeutic effect in an in vivo mouse model for dry eye disease. Chem. Commun. 2019. 55 91, 13657-13660
4. Hyun, S. #; Lee, Y. #; Jin, S. M.; Cho, J.; Park, J.; Hyeon, C.; Kim, K.-S.; Lee, Y.; Yu, J. Oligomer Formation Propensities of Dimeric Bundle Peptides Correlate with Cell Penetration Abilities, ACS Central Sci. 2018, 4, 7, 885-893. #co-first author
5. Hyun, S.; Choi, Y.; Lee, H. N.; Lee, C.; Oh, D.; Lee, D.-K.; Lee, C.; Lee, Y.; Yu, J., Construction of histidine-containing hydrocarbon stapled cell penetrating peptides for in vitro and in vivo delivery of siRNAs. Chem. Sci. 2018, 9 (15), 3820-3827.
6. Pai, J.; Hyun, S.; Hyun, J. Y.; Park, S.-H.; Kim, W.-J.; Bae, S.-H.; Kim, N.-K.; Yu, J.; Shin, I., Screening of pre-miRNA-155 Binding Peptides for Apoptosis Inducing Activity Using Peptide Microarrays. J. Am. Chem. Soc. 2016, 138 (3), 857-867.
7. Kim, S.#; Hyun, S. #; Lee, Y.; Yu, J.; Lee, Y., Nonhemolytic Cell-Penetrating Peptides: Site Specific Introduction of Glutamine and Lysine Residues into the α-Helical Peptide Causes Deletion of Its Direct Membrane Disrupting Ability but Retention of Its Cell Penetrating Ability. Biomacromolecules 2016, 17 (9), 3007-15. #co-first author
8. Jang, S. #; Hyun, S. #; Kim, S.; Lee, S.; Lee, I.-S.; Baba, M.; Lee, Y.; Yu, J., Cell-Penetrating, Dimeric α-Helical Peptides: Nanomolar Inhibitors of HIV-1 Transcription. Angew. Chem., Int. Ed. 2014, 53 (38), 10086-10089. #co-first author
9. Hyun, S. #; Lee, S. #; Kim, S.; Jang, S.; Yu, J.; Lee, Y., Apoptosis Inducing, Conformationally Constrained, Dimeric Peptide Analogs of KLA with Submicromolar Cell Penetrating Abilities. Biomacromolecules 2014, 15 (10), 3746-3752.
10. Lee, Y.#; Hyun, S. #; Kim, H. J.; Yu, J., Amphiphilic helical peptides containing two acridine moieties display picomolar affinity toward HIV-1 RRE and TAR. Angew. Chem., Int. Ed. 2008, 47 (1), 134-137. #co-first author
11. Hyun, S.; Kim, H. J.; Lee, N. J.; Lee, K. H.; Lee, Y.; Ahn, D. R.; Kim, K.; Jeong, S.; Yu, J., α-Helical Peptide Containing N,N-Dimethyl Lysine Residues Displays Low-Nanomolar and Highly Specific Binding to RRE RNA. J. Am. Chem. Soc. 2007, 129 (15), 4514-4515.